Ku70 protein

Known as: X ray Repair Cross Complementing Protein 6, X-ray Repair Cross-Complementing Protein 6, Ku70 
X-ray repair cross-complementing protein 6 (609 aa, ~70 kDa) is encoded by the human XRCC6 gene. This protein plays a role in DNA non-homologous end… (More)
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
PURPOSE This study was aimed at detecting and characterizing circulating tumor cells (CTC) before and after neoadjuvant therapy… (More)
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Highly Cited
2007
Highly Cited
2007
Viable tumour-derived epithelial cells (circulating tumour cells or CTCs) have been identified in peripheral blood from cancer… (More)
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Highly Cited
2006
Highly Cited
2006
DNA double-strand break (DSB) repair by nonhomologous end joining (NHEJ) requires the assembly of several proteins on DNA ends… (More)
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Highly Cited
2005
Highly Cited
2005
Rickettsia conorii, a strictly intracellular and category C priority bacterial pathogen (NIAID), invades different mammalian… (More)
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Highly Cited
2005
Highly Cited
2005
Histone deacetylase inhibitors (HDACIs) are therapeutic drugs that inhibit deacetylase activity, thereby increasing acetylation… (More)
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Highly Cited
2004
Highly Cited
2004
Apoptosis is a key tumor suppression mechanism that can be initiated by activation of the proapoptotic factor Bax. The Ku70 DNA… (More)
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Highly Cited
2003
Highly Cited
2003
Bax induces mitochondrial-dependent cell death signals in mammalian cells. However, the mechanism of how Bax is kept inactive has… (More)
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Highly Cited
2002
Highly Cited
2002
The Ku70/80 heterodimer is a critical component of the non-homologous end-joining (NHEJ) pathway and of the telomere cap in yeast… (More)
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Highly Cited
1999
Highly Cited
1999
Double-strand DNA breaks (DSBs) pose a major threat to living cells, and several mechanisms for repairing these lesions have… (More)
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Highly Cited
1997
Highly Cited
1997
Ku is a complex of two proteins, Ku70 and Ku80, and functions as a heterodimer to bind DNA double-strand breaks (DSB) and… (More)
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