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Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1
TLDR
It is shown that Esp1 causes the dissociation of Scc1 from chromosomes by stimulating its cleavage by proteolysis, and a mutant SCC1 is described that is resistant to Esp1-dependent cleavage and which blocks both sister-chromatid separation and the dissociations from chromosomes. Expand
Molecular cloning and expression of brain-derived neurotrophic factor
TLDR
The full primary structure of brain-derived neurotrophic factor is reported and it is established that these two neurotrophic factors are related both functionally and structurally. Expand
A major transmembrane protein of Golgi-derived COPI-coated vesicles involved in coatomer binding
TLDR
Biochemical analysis revealed that p23 is enriched in vesicles by a factor of approximately 20, as compared with the donor Golgi fraction, and is present in amounts stoichiometric to the small GTP-binding protein ADP-ribosylation factor (ARF) and coatomer. Expand
Identification of in vivo substrates of the chaperonin GroEL
TLDR
It is shown that GroEL interacts strongly with a well-defined set of approximately 300 newly translated polypeptides, including essential components of the transcription/translation machinery and metabolic enzymes. Expand
Tim9, a new component of the TIM22·54 translocase in mitochondria
TLDR
Tim9, a new component of the TIM22·54 import machinery, which mediates transport of proteins into the inner membrane of mitochondria, shares sequence similarity with Tim10 and Tim12 and is located in the mitochondrial intermembrane space. Expand
A multiprotein complex mediates the ATP-dependent assembly of spliceosomal U snRNPs
TLDR
It is shown that assembly of U1 snRNP depends on ATP, the first direct evidence that a complex containing SMN and Gemin2 mediates the active assembly of spliceosomal U snRNPs. Expand
A novel mediator of class II gene transcription with homology to viral immediate-early transcriptional regulators
TLDR
Structural and functional similarities, including sequence homology to domains essential for cofactor function, cofactor activity, promiscuity with respect to transcriptional activators, and interactions with components of the basal transcription machinery, relate this novel cellular cofactor to viral immediate-early transcriptional regulators. Expand
Tom5 functionally links mitochondrial preprotein receptors to the general import pore
TLDR
It is concluded that Tom5 represents a functional link between surface receptors and GIP, and is part of an ‘acid chain’ that guides the stepwise transport of positively charged mitochondrial targeting sequences. Expand
Pheromones trigger filamentous growth in Ustilago maydis.
TLDR
It is demonstrated that binding of pheromone to the receptor can induce a morphological switch from yeast‐like to filamentous growth in certain strains of the smut fungus Ustilago. Expand
Matching of oligoclonal immunoglobulin transcriptomes and proteomes of cerebrospinal fluid in multiple sclerosis
TLDR
Compared the Ig transcriptomes of B cells with the corresponding Ig proteomes in CSF samples from four subjects with multiple sclerosis, it is shown that CSF B cells indeed produce the oligoclonal Ig bands. Expand
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