Skip to search formSkip to main contentSkip to account menu

Ku autoantigen

Known as: Antigen, G22P1, Heterodimer, Ku, Ku 
An ATP-dependent DNA HELICASE that preferentially binds SINGLE-STRANDED DNA. It is a heterodimer consisting of an 80 kDa subunit (XRCC5) and 70 kDa… 
National Institutes of Health

Related topics

Related topics

15 relations
In BloodKu Ab:PrThr:Pt:Body fld:Ord:IAKu Ab:PrThr:Pt:Ser:OrdKu Ab:Titr:Pt:Ser:Qn:IF

Narrower (3)

Ku autoantigen, 80 kDaKu70 proteinXRCC5 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Securin induces genetic instability in colorectal cancer by inhibiting double-stranded DNA repair activity.
Genetic instability (GI) is a hallmark feature of tumor development. Securin, also known as pituitary tumor transforming gene… 
Highly Cited
2005
Highly Cited
2005
Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and γ radiation
Ku protein is a heterodimer (Ku70 and Ku86) known to play an important role in V(D)J recombination, apoptosis, telomere fusion… 
Highly Cited
2004
Highly Cited
2004
Identification and Biochemical Characterization of a Werner's Syndrome Protein Complex with Ku70/80 and Poly(ADP-ribose) Polymerase-1*
Werner's syndrome (WS) is an inherited disease characterized by genomic instability and premature aging. The WS gene encodes a… 
Highly Cited
2003
Highly Cited
2003
An Rpb4/Rpb7-Like Complex in Yeast RNA Polymerase III Contains the Orthologue of Mammalian CGRP-RCP
ABSTRACT The essential C17 subunit of yeast RNA polymerase (Pol) III interacts with Brf1, a component of TFIIIB, suggesting a… 
Review
2002
Review
2002
DNA-dependent protein kinase complex: a multifunctional protein in DNA repair and damage checkpoint.
Highly Cited
2000
Highly Cited
2000
Lysyl Oxidase Activates the Transcription Activity of Human Collagene III Promoter
Lysyl oxidase is an extracellular enzyme that controls the maturation of collagen and elastin. Lysyl oxidase and collagen III… 
Highly Cited
1997
Highly Cited
1997
Heat inactivation of Ku autoantigen: possible role in hyperthermic radiosensitization.
Heat shock prior, during, or immediately after ionizing radiation synergistically increases cell killing, a phenomenon termed… 
Highly Cited
1997
Highly Cited
1997
Ku proteins join DNA fragments as shown by atomic force microscopy.
The binding of the Ku protein to DNA was investigated using the atomic force microscope. Ku was found to bind predominantly to… 
Highly Cited
1995
Highly Cited
1995
Purification of the sequence‐specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen.
The common promoter region of the human collagen type IV genes COL4A1 and COL4A2 comprises a C5TC7 sequence (‘CTC box’) which is… 
Highly Cited
1995
Highly Cited
1995
Absence of autoantigen Ku in mature human neutrophils and human promyelocytic leukemia line (HL-60) cells and lymphocytes undergoing apoptosis
The Ku autoantigen is a heterodimer of 70- and 80-kD proteins recognized by autoantibodies from patients with systemic lupus… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)