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DNA Helicases

Known as: DNA unwinding enzyme, Helicases, Helicase 
Helicases are a class of enzymes that utilize the energy of ATP hydrolysis to promote unwinding of 1.) RNA during transcription, splicing and… Expand
National Institutes of Health

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Highly Cited
2008
Highly Cited
2008
A key cellular response to DNA double-strand breaks (DSBs) is 5'-to-3' DSB resection by nucleases to generate regions of ssDNA… Expand
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Highly Cited
2006
Highly Cited
2006
The innate immune system senses viral infection by recognizing a variety of viral components (including double-stranded (ds)RNA… Expand
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Highly Cited
2005
Highly Cited
2005
Antiviral immunity against a pathogen is mounted upon recognition by the host of virally associated structures. One of these… Expand
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Highly Cited
2005
Highly Cited
2005
Type I interferons are central mediators for antiviral responses. Using high-throughput functional screening of interferon… Expand
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Highly Cited
2004
Highly Cited
2004
MicroRNAs (miRNAs) are a growing family of small non-protein-coding regulatory genes that regulate the expression of homologous… Expand
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Highly Cited
2004
Highly Cited
2004
Polymerase chain reaction is the most widely used method for in vitro DNA amplification. However, it requires thermocycling to… Expand
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Highly Cited
2003
Highly Cited
2003
Mutations in the Saccharomyces cerevisiae gene SRS2 result in the yeast's sensitivity to genotoxic agents, failure to recover or… Expand
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Review
2003
Review
2003
  • I. Hickson
  • Nature Reviews Cancer
  • 2003
  • Corpus ID: 19958277
RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of the five known family members in humans… Expand
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Highly Cited
1997
Highly Cited
1997
Werner syndrome (WS) is an uncommon autosomal recessive disorder characterized by premature aging. The clinical manifestations of… Expand
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Highly Cited
1995
Highly Cited
1995
The Bloom's syndrome (BS) gene, BLM, plays an important role in the maintenance of genomic stability in somatic cells. A… Expand
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