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DNA Helicases

Known as: DNA unwinding enzyme, Helicases, Helicase 
Helicases are a class of enzymes that utilize the energy of ATP hydrolysis to promote unwinding of 1.) RNA during transcription, splicing and… Expand
National Institutes of Health

Related topics

Related topics

50 relations
ATP HydrolysisAdenosine TriphosphatasesBLM protein, humanCHD4 protein, human
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Narrower (30)

Atrx protein, mouseCHD1L protein, humanCHD3 protein, DrosophilaCHD3 protein, human
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Papers overview

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Highly Cited
2008
Highly Cited
2008
DNA helicases Sgs1 and BLM promote DNA double-strand break resection.
A key cellular response to DNA double-strand breaks (DSBs) is 5'-to-3' DSB resection by nucleases to generate regions of ssDNA… Expand
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Highly Cited
2006
Highly Cited
2006
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
The innate immune system senses viral infection by recognizing a variety of viral components (including double-stranded (ds)RNA… Expand
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Highly Cited
2005
Highly Cited
2005
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
Antiviral immunity against a pathogen is mounted upon recognition by the host of virally associated structures. One of these… Expand
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Highly Cited
2005
Highly Cited
2005
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Type I interferons are central mediators for antiviral responses. Using high-throughput functional screening of interferon… Expand
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Highly Cited
2004
Highly Cited
2004
The Microprocessor complex mediates the genesis of microRNAs
MicroRNAs (miRNAs) are a growing family of small non-protein-coding regulatory genes that regulate the expression of homologous… Expand
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Highly Cited
2004
Highly Cited
2004
Helicase‐dependent isothermal DNA amplification
Polymerase chain reaction is the most widely used method for in vitro DNA amplification. However, it requires thermocycling to… Expand
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Highly Cited
2003
Highly Cited
2003
DNA helicase Srs2 disrupts the Rad51 presynaptic filament
Mutations in the Saccharomyces cerevisiae gene SRS2 result in the yeast's sensitivity to genotoxic agents, failure to recover or… Expand
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Review
2003
Review
2003
RecQ helicases: caretakers of the genome
  • I. Hickson
  • Nature Reviews Cancer
  • 2003
    • Corpus ID: 19958277
RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of the five known family members in humans… Expand
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Highly Cited
1997
Highly Cited
1997
The Werner syndrome protein is a DNA helicase
Werner syndrome (WS) is an uncommon autosomal recessive disorder characterized by premature aging. The clinical manifestations of… Expand
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Highly Cited
1995
Highly Cited
1995
The Bloom's syndrome gene product is homologous to RecQ helicases
The Bloom's syndrome (BS) gene, BLM, plays an important role in the maintenance of genomic stability in somatic cells. A… Expand
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