DNA Helicases

Known as: DNA unwinding enzyme, Helicases, Helicase 
Helicases are a class of enzymes that utilize the energy of ATP hydrolysis to promote unwinding of 1.) RNA during transcription, splicing and… (More)
National Institutes of Health

Related topics

Related topics

50 relations
ATP HydrolysisAdenosine TriphosphatasesBLM protein, humanCHD4 protein, human
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Narrower (29)

Atrx protein, mouseCHD1L protein, humanCHD3 protein, DrosophilaChd1l protein, mouse
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Papers overview

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Review
2011
Review
2011
DNA interstrand crosslink repair and cancer
Interstrand crosslinks (ICLs) are highly toxic DNA lesions that prevent transcription and replication by inhibiting DNA strand… (More)
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Highly Cited
2008
Highly Cited
2008
DNA helicases Sgs1 and BLM promote DNA double-strand break resection.
A key cellular response to DNA double-strand breaks (DSBs) is 5'-to-3' DSB resection by nucleases to generate regions of ssDNA… (More)
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Review
2008
Review
2008
Translocation and unwinding mechanisms of RNA and DNA helicases.
Helicases and remodeling enzymes are ATP-dependent motor proteins that play a critical role in every aspect of RNA and DNA… (More)
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Highly Cited
2006
Highly Cited
2006
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
The innate immune system senses viral infection by recognizing a variety of viral components (including double-stranded (ds)RNA… (More)
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Highly Cited
2005
Highly Cited
2005
Shared and unique functions of the DExD/H-box helicases RIG-I, MDA5, and LGP2 in antiviral innate immunity.
The cellular protein retinoic acid-inducible gene I (RIG-I) senses intracellular viral infection and triggers a signal for innate… (More)
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Review
2003
Review
2003
RecQ helicases: caretakers of the genome
RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of the five known family members in humans… (More)
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Highly Cited
2002
Highly Cited
2002
Identification of genes that are associated with DNA repeats in prokaryotes.
Using in silico analysis we studied a novel family of repetitive DNA sequences that is present among both domains of the… (More)
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Highly Cited
2001
Highly Cited
2001
BACH1, a Novel Helicase-like Protein, Interacts Directly with BRCA1 and Contributes to Its DNA Repair Function
BRCA1 interacts in vivo with a novel protein, BACH1, a member of the DEAH helicase family. BACH1 binds directly to the BRCT… (More)
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Highly Cited
1995
Highly Cited
1995
The Bloom's syndrome gene product is homologous to RecQ helicases
The Bloom's syndrome (BS) gene, BLM, plays an important role in the maintenance of genomic stability in somatic cells. A… (More)
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Highly Cited
1989
Highly Cited
1989
Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes.
In the course of systematic analysis of protein sequences containing the purine NTP-binding motif, a new superfamily was… (More)
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