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DNA Helicases
Known as:
DNA unwinding enzyme
, Helicases
, Helicase
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Helicases are a class of enzymes that utilize the energy of ATP hydrolysis to promote unwinding of 1.) RNA during transcription, splicing and…
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National Institutes of Health
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Related topics
Related topics
50 relations
ATP Hydrolysis
Adenosine Triphosphatases
BLM protein, human
CHD4 protein, human
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Narrower (30)
Atrx protein, mouse
CHD1L protein, human
CHD3 protein, Drosophila
CHD3 protein, human
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
DNA helicases Sgs1 and BLM promote DNA double-strand break resection.
S. Gravel
,
J. R. Chapman
,
C. Magill
,
S. Jackson
Genes & development
2008
Corpus ID: 25670500
A key cellular response to DNA double-strand breaks (DSBs) is 5'-to-3' DSB resection by nucleases to generate regions of ssDNA…
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Highly Cited
2006
Highly Cited
2006
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
H. Kato
,
O. Takeuchi
,
+15 authors
S. Akira
Nature
2006
Corpus ID: 2270879
The innate immune system senses viral infection by recognizing a variety of viral components (including double-stranded (ds)RNA…
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Highly Cited
2005
Highly Cited
2005
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus
E. Meylan
,
J. Curran
,
+4 authors
J. Tschopp
Nature
2005
Corpus ID: 4391603
Antiviral immunity against a pathogen is mounted upon recognition by the host of virally associated structures. One of these…
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Highly Cited
2005
Highly Cited
2005
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
T. Kawai
,
Ken Takahashi
,
+6 authors
S. Akira
Nature Immunology
2005
Corpus ID: 31479259
Type I interferons are central mediators for antiviral responses. Using high-throughput functional screening of interferon…
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Highly Cited
2004
Highly Cited
2004
Helicase‐dependent isothermal DNA amplification
M. Vincent
,
Yan Xu
,
H. Kong
EMBO reports
2004
Corpus ID: 14107228
Polymerase chain reaction is the most widely used method for in vitro DNA amplification. However, it requires thermocycling to…
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Highly Cited
2004
Highly Cited
2004
The Microprocessor complex mediates the genesis of microRNAs
R. Gregory
,
Kai-ping Yan
,
+4 authors
R. Shiekhattar
Nature
2004
Corpus ID: 4389261
MicroRNAs (miRNAs) are a growing family of small non-protein-coding regulatory genes that regulate the expression of homologous…
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Highly Cited
2003
Highly Cited
2003
DNA helicase Srs2 disrupts the Rad51 presynaptic filament
L. Krejci
,
S. V. Komen
,
+5 authors
P. Sung
Nature
2003
Corpus ID: 4391277
Mutations in the Saccharomyces cerevisiae gene SRS2 result in the yeast's sensitivity to genotoxic agents, failure to recover or…
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Review
2003
Review
2003
RecQ helicases: caretakers of the genome
I. Hickson
Nature Reviews Cancer
2003
Corpus ID: 19958277
RecQ helicases are highly conserved from bacteria to man. Germline mutations in three of the five known family members in humans…
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Highly Cited
1997
Highly Cited
1997
The Werner syndrome protein is a DNA helicase
M. Gray
,
Jiang-Cheng Shen
,
+5 authors
L. Loeb
Nature Genetics
1997
Corpus ID: 20587915
Werner syndrome (WS) is an uncommon autosomal recessive disorder characterized by premature aging. The clinical manifestations of…
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Review
1996
Review
1996
Mechanisms of helicase-catalyzed DNA unwinding.
T. Lohman
,
K. Bjornson
Annual review of biochemistry
1996
Corpus ID: 5679912
DNA helicases are essential motor proteins that function to unwind duplex DNA to yield the transient single-stranded DNA…
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