KRAS gene

Known as: K-ras Genes, Oncogene K-Ras, C-KRAS 
Human Oncogene K-Ras is a mutated variant of KRAS2 Gene, which encodes two alternative isoforms of monomeric p21 K-RAS protein, a monomeric GTPase… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
Cancer cells that express oncogenic alleles of RAS typically require sustained expression of the mutant allele for survival, but… (More)
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Highly Cited
2012
Highly Cited
2012
Pancreatic cancer is almost invariably associated with mutations in the KRAS gene, most commonly KRASG12D, that result in a… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Following the discovery that mutant KRAS is associated with resistance to anti-epidermal growth factor receptor (EGFR… (More)
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Highly Cited
2009
Highly Cited
2009
The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are aggressive and respond poorly to standard… (More)
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Highly Cited
2009
Highly Cited
2009
An alternative to therapeutic targeting of oncogenes is to perform "synthetic lethality" screens for genes that are essential… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE The antiepidermal growth factor receptor antibody cetuximab shows activity in irinotecan-refractory metastatic colorectal… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE To evaluate the effect of KRAS and epidermal growth factor receptor (EGFR) genotype on the response to erlotinib… (More)
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Highly Cited
2006
Highly Cited
2006
PURPOSE This study evaluated the mutational profile of epidermal growth factor receptor (EGFR) and KRAS in non-small cell lung… (More)
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Highly Cited
2006
Highly Cited
2006
The development of targeted therapies has created a pressing clinical need for the rapid and robust molecular characterisation of… (More)
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Highly Cited
2003
Highly Cited
2003
Activating mutations in KRAS and in one of its downstream mediators, BRAF, have been identified in a variety of human cancers. To… (More)
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