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KRAS wt Allele

Known as: K-Ras 2A, K-RAS2B, C-K-RAS 
Human KRAS wild-type allele is located in the vicinity of 12p12.1 and is approximately 45 kb in length. This allele, which encodes GTPase KRas… 
National Institutes of Health

Related topics

Related topics

23 relations
12p12.1Adenocarcinoma of ampulla of VaterAdenocarcinoma of lung (disorder)Ampulla of Vater Intestinal-Type Adenoma

Broader (1)

KRAS gene

Papers overview

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2005
2005
Colorectal adenomas with a low frequency of ki‐ras mutations: a sample from a population with a low mortality rate from colorectal cancer
Objective  To detect and analyse ki‐ras point mutations in colorectal adenomas and carcinomas in patients from Greece, where… 
Review
2005
Review
2005
Prognostic and predictive factors in colorectal cancer: Kirsten Ras in CRC (RASCAL) and TP53CRC collaborative studies.
Mutations in the Ki-ras and TP53 genes are the most frequently observed genetic alterations in colorectal cancer (CRC). Ki-ras… 
Highly Cited
2003
Highly Cited
2003
A prospective study of circulating mutant KRAS2 in the serum of patients with colorectal neoplasia: strong prognostic indicator in postoperative follow up
Background and aims: Mutant tumour derived DNA has been detected in the sera of colorectal cancer patients. We investigated if… 
2002
2002
Low sensitivity of the ki-ras polymerase chain reaction for diagnosing pancreatic cancer from pancreatic juice and bile: a multicenter prospective trial.
PURPOSE Early detection of pancreatic cancer using molecular markers may improve outcome. Mutations of the ki-ras oncogene are… 
Review
2000
Review
2000
The C3(1)/SV40 T-antigen transgenic mouse model of mammary cancer: ductal epithelial cell targeting with multistage progression to carcinoma
The 5′ flanking region of the C3(1) component of the rat prostate steroid binding protein (PSBP) has been used to successfully… 
1995
1995
Overexpression of protein kinase C beta 1 in the SW480 colon cancer cell line causes growth suppression.
Using a retroviral vector system we have established derivatives of the E8 subclone of the human colon cancer cell line SW480… 
Highly Cited
1994
Highly Cited
1994
c-k-ras and p53 mutations occur very early in adenocarcinoma of the lung.
1988
1988
Aberrant expression of the K-ras proto-oncogene in B-cell malignancies.
The proto-oncogenes have the capacity for conversion to an oncogene that is capable of inducing or maintaining the transformed… 
1987
1987
Aberrant oncogene expression in uncultured human sarcoma and melanoma.
Protooncogenes have the ability to induce and/or maintain the transformed state when they are overly expressed or altered by… 
1986
1986
Sequential expression of proto-oncogenes during a mouse erythroleukemia cell differentiation.
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