D. Henne-Bruns

Publications441
h-index46
Citations8,158
Highly Influential Citations224
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Systemic and local immunosuppression in pancreatic cancer patients.
TLDR
Analysis of parameters in 116 patients suffering from pancreatic ductal adenocarcinoma presents strong evidence for an active systemic immunosuppression in pancreatic cancer, as shown by elevated IL-10 and TGF-beta1/2 serum levels as well as the presence of disseminated tumor cells.
Allelic loss is often the first hit in the biallelic inactivation of the p53 and DPC4 genes during pancreatic carcinogenesis.
Human pancreatic adenocarcinomas express Fas and Fas ligand yet are resistant to Fas-mediated apoptosis.
TLDR
Evidence for the production of FasL by pancreatic tumor cells is presented and the recently proposed "counterattack model" for local deletion of tumor-reactive T-cells by tumor cell-derived FasL is supported.
Long-term experience on surgical treatment of alveolar echinococcosis
TLDR
Curative surgery for AE is feasible if the parasitic mass is removable entirely and the earlier the stage, the more frequent is R0 resectability, and the benefit of palliative surgery is uncertain.
Interleukin-4 enhances proliferation of human pancreatic cancer cells: evidence for autocrine and paracrine actions
TLDR
It is reported for the first time that IL-4 significantly enhanced the growth of five out of six cultured pancreatic cancer cell lines in a dose-dependent manner in association with an increased fraction of cells in S-phase, and the possibility that cancer-derivedIL-4 may suppress cancer-directed immunosurveillance in vivo in addition to its growth-promoting effects, thereby facilitating pancreatic tumour growth and metastasis.
Impact of psychotherapeutic support on gastrointestinal cancer patients undergoing surgery: survival results of a trial.
TLDR
The results of this study indicate that patients with gastrointestinal cancer, particularly those who are female and those who undergo surgery for stomach, pancreatic, primary liver or colorectal cancer, benefit from a formal program of psychotherapeutic support in terms of survival.
FAP-1 in pancreatic cancer cells: functional and mechanistic studies on its inhibitory role in CD95-mediated apoptosis.
TLDR
Results show that FAP-1 can protect pancreatic carcinoma cells from CD95-mediated apoptosis, probably by preventing anti-CD95-induced translocation of CD95 from intracellular stores to the cell surface.
Parathyroidectomy, elevated depression scores, and suicidal ideation in patients with primary hyperparathyroidism: results of a prospective multicenter study.
TLDR
Depression, anxiety, and decreased HRQOL appear to be related to pHPT, and Successful parathyroidectomy seems to reduce psychopathologic symptoms and improveHRQOL in this setting.
Immunocytological detection of micrometastatic cells: Comparative evaluation of findings in the peritoneal cavity and the bone marrow of gastric, colorectal and pancreatic cancer patients
TLDR
Using immunocytology, the peritoneal cavity and the bone marrow of 147 patients with gastric, colorectal and pancreatic cancer for micrometastatic cells was investigated and monoclonal antibodies against tumor‐associated antigens (TAA) were analyzed.
The retroperitoneal resection margin and vessel involvement are important factors determining survival after pancreaticoduodenectomy for ductal adenocarcinoma of the head of the pancreas
TLDR
The data suggest that tumour invasion of the retroperitoneal resection margin and large vessel involvement are the major factors determining survival in patients with pancreatic cancer.
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