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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
TLDR
It is proposed that, from its earliest stages, cancer development is associated with DNA replication stress, which leads to DNA double-strand breaks, genomic instability and selective pressure for p53 mutations.
Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry.
TLDR
A previously uncharacterized method for high-throughput DNA methylation analysis that utilizes MALDI-TOF mass spectrometry (MS) analysis of base-specifically cleaved amplification products is presented and it is demonstrated that the quantitative methylation results allow accurate classification of samples according to their histopathology.
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25
TLDR
The results provide compelling evidence of a locus at 15q25 predisposing to lung cancer, and reinforce interest in nicotinic acetylcholine receptors as potential disease candidates and chemopreventative targets.
Extent of MGMT promoter methylation correlates with outcome in glioblastomas given temozolomide and radiotherapy
TLDR
These data indicate that MGMT methylation is prognostically significant in glioblastomas given chemoradiotherapy in the routine clinic; furthermore, the extent of methylation may be used to provide additional prognostic stratification.
Lung cancer susceptibility locus at 5p15.33
TLDR
The susceptibility region contains two genes, TERT and CLPTM1L, suggesting that one or both may have a role in lung cancer etiology, and two uncorrelated disease markers at 5p15.33 are detected.
The LLP risk model: an individual risk prediction model for lung cancer
TLDR
If independent validation studies confirm these results, the LLP risk models’ application as the first stage in an early detection strategy is a logical evolution in patient care.
A prognostic DNA methylation signature for stage I non-small-cell lung cancer.
TLDR
The DNA methylation signature of NSCLC affects the outcome of stage I patients, and it can be practically determined by user-friendly polymerase chain reaction assays.
Cytoglobin, the newest member of the globin family, functions as a tumor suppressor gene.
TLDR
The first direct functional evidence for CYGB, the newest member of the globin family, as a tumor suppressor gene is shown, using biopsies and sputum samples from patients with and without lung cancer.
Promoter methylation of P16, RARβ, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing
TLDR
This data demonstrated p16 promoter methylation in a highly tumour specific pattern and Cytoglobin is a novel candidate tumour suppressor gene highly methylated in upper aero-digestive tract squamous cancer.
SHOX2 DNA Methylation is a Biomarker for the diagnosis of lung cancer based on bronchial aspirates
TLDR
Hypermethylation of SHOX2 in bronchial aspirates appears to be a clinically useful tumor marker for identifying subjects with lung carcinoma, especially if histological and cytological findings after bronchoscopy are ambiguous.
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