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De novo CD5+ diffuse large B-cell lymphoma: a clinicopathologic study of 109 patients.
De novo CD5+ diffuse large B-cell lymphoma (CD5+ DLBCL) is known to have phenotypically and genotypically different characteristics than CD5- DLBCL and mantle cell lymphoma (MCL). To furtherExpand
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Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system.
Gangliosides, sialic acid-containing glycosphingolipids, are abundant in the vertebrate (mammalian) nervous system. Their composition is spatially and developmentally regulated, and gangliosides haveExpand
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Peptides derived from a wild-type murine proto-oncogene c-erbB-2/HER2/neu can induce CTL and tumor suppression in syngeneic hosts.
In this analysis, we examined whether peptides derived from a wild-type murine proto-oncogene, c-erbB-2, function as tumor rejection Ags. Expression of murine c-erbB-2 examined by means of reverseExpand
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Classification of current anticancer immunotherapies
During the past decades, anticancer immunotherapy has evolved from a promising therapeutic option to a robust clinical reality. Many immunotherapeutic regimens are now approved by the US Food andExpand
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Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody.
For the isolation of ganglioside GD3 synthase (EC cDNA, we developed an expression cloning approach that used an anti-GD2 monoclonal antibody for selection. A host recipient cell line thatExpand
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Agonist-induced regulation of myosin phosphatase activity in human platelets through activation of Rho-kinase.
Human platelets contained about 15 times lower amounts of Rho-kinase than Ca2+/calmodulin-dependent myosin light chain (MLC) kinase. Anti-myosin-binding subunit (MBS) antibody coimmunoprecipitatedExpand
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CD8+CD122+ regulatory T cells recognize activated T cells via conventional MHC class I-alphabetaTCR interaction and become IL-10-producing active regulatory cells.
CD8(+)CD122(+) regulatory T cells (CD8(+)CD122(+) Treg) are naturally occurring Treg that effectively suppress the proliferation and IFN-gamma production of both CD8(+) and CD4(+) target cells. ThisExpand
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De novo CD5‐positive diffuse large B‐cell lymphoma: clinical characteristics and therapeutic outcome
To determine the clinical significance of CD5 expression in diffuse large B‐cell lymphoma (DLBL) without a clinical history of low‐grade B‐cell lymphoma, we have reviewed the clinical features andExpand
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[DNA vaccine].
The study of DNA vaccine has been started after the initial report showing that plasmids encoding a reporter gene are able to induce in vivo expression of the encoded protein. While some of DNAExpand
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Eradication of established tumors by CD8+ T cell adoptive immunotherapy.
We generated the DUC18 T cell receptor transgenic mouse expressing an H-2Kd -restricted transgenic T cell receptor specific for the syngeneic CMS5 fibrosarcoma rejection antigen mutatedExpand
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