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Iron Chelating Activity [MoA]

Known as: Iron Chelating Activity, Iron Chelator 
National Institutes of Health

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CHROMIUM PICOLINATECHROMIUM PICOLINATE 0.2 MG Oral CapsuleDeferoxamineIron Chelating Agents

Papers overview

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Highly Cited
2010
Highly Cited
2010
Tailoring iron chelation by iron intake and serum ferritin: the prospective EPIC study of deferasirox in 1744 patients with transfusion-dependent anemias
Background Following a clinical evaluation of deferasirox (Exjade®) it was concluded that, in addition to baseline body iron… 
Highly Cited
2010
Highly Cited
2010
Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation
The biological mode of action of artemisinin, a potent antimalarial, has long been controversial. Previously we established a… 
Highly Cited
2008
Highly Cited
2008
Bmc Complementary and Alternative Medicine Antioxidant and Free Radical Scavenging Activity of Spondias Pinnata
Background: Many diseases are associated with oxidative stress caused by free radicals. Current research is directed towards… 
Highly Cited
2006
Highly Cited
2006
Iron chelation in the biological activity of curcumin.
Highly Cited
2004
Highly Cited
2004
Ironing Iron Out in Parkinson's Disease and Other Neurodegenerative Diseases with Iron Chelators: A Lesson from 6‐Hydroxydopamine and Iron Chelators, Desferal and VK‐28
Abstract: In Parkinson's disease (PD) and its neurotoxin‐induced models, 6‐hydroxydopamine (6‐OHDA) and N‐methyl‐4‐phenyl‐1,2,3,6… 
Highly Cited
2003
Highly Cited
2003
Safety and effectiveness of long-term therapy with the oral iron chelator deferiprone.
The identification of a safe, orally active iron chelator is critically important for the prevention of morbidity and early death… 
Highly Cited
2003
Highly Cited
2003
Bach1 Functions as a Hypoxia-inducible Repressor for the Heme Oxygenase-1 Gene in Human Cells*
Heme oxygenase 1 (HO-1) catalyzes heme breakdown, eventually releasing iron, carbon monoxide, and bilirubin IXα. HO-1 is induced… 
Highly Cited
1992
Highly Cited
1992
Neutrophil induced oxidative injury of cardiac myocytes. A compartmented system requiring CD11b/CD18-ICAM-1 adherence.
We have previously shown that cytokines and postischemic cardiac lymph induce expression of intercellular adhesion molecule-1… 
Highly Cited
1988
Highly Cited
1988
Adriamycin-induced free radical formation in the perfused rat heart: implications for cardiotoxicity.
Adriamycin is an anthracycline drug with a wide spectrum of clinical antineoplastic activity. However, the usefulness of the drug… 
Highly Cited
1984
Highly Cited
1984
Cell killing and DNA damage by hydrogen peroxide are mediated by intracellular iron.
Phenanthroline, a strong iron chelator, prevents both the formation of DNA single-strand breaks and the killing of mouse cells… 
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