Iron Chelating Agents

Known as: agent chelating iron, chelate iron, Iron.chelated 
Organic chemicals that form two or more coordination links with an iron ion. Once coordination has occurred, the complex formed is called a chelate… (More)
National Institutes of Health

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1,10-phenanthroline2,3-dihydroxybenzoic acid3-hydroxy-4-pyridoneFe(III)-EDTA
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Chelating AgentsChelation TherapyHemoglobinIron Chelating Activity [MoA]
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Papers overview

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Review
2009
Review
2009
Iron in innate immunity: starve the invaders.
Iron is essential for nearly all living organisms. Innate immunity effectively restricts iron availability to microbial invaders… (More)
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Highly Cited
2007
Highly Cited
2007
Selective iron chelation in Friedreich ataxia: biologic and clinical implications.
Genetic disorders of iron metabolism and chronic inflammation often evoke local iron accumulation. In Friedreich ataxia… (More)
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Highly Cited
2005
Highly Cited
2005
Iron and Pseudomonas aeruginosa biofilm formation.
Iron serves as a signal in Pseudomonas aeruginosa biofilm development. We examined the influence of mutations in known and… (More)
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Highly Cited
2002
Highly Cited
2002
Interactions of flavonoids with iron and copper ions: a mechanism for their antioxidant activity.
The metal chelating properties of flavonoids suggest that they may play a role in metal-overload diseases and in all oxidative… (More)
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Highly Cited
1999
Highly Cited
1999
Competition among marine phytoplankton for different chelated iron species
Dissolved-iron availability plays a critical role in controlling phytoplankton growth in the oceans,. The dissolved iron is… (More)
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Review
1998
Review
1998
TonB-dependent iron acquisition: mechanisms of siderophore-mediated active transport.
Cells growing in aerobic environments have developed intricate strategies to overcome the scarcity of iron, an essential nutrient… (More)
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Highly Cited
1998
Highly Cited
1998
Quercetin prevents DNA single strand breakage and cytotoxicity caused by tert-butylhydroperoxide: free radical scavenging versus iron chelating mechanism.
Although the antioxidant properties of flavonoids are well documented, it is still unclear whether these effects are dependent on… (More)
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Highly Cited
1997
Highly Cited
1997
Protection against oxidative damage of erythrocyte membrane by the flavonoid quercetin and its relation to iron chelating activity.
Incubation of glutathione (GSH) depleted mouse erythrocytes with the oxidants phenylhydrazine, acrolein, divicine and isouramil… (More)
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Highly Cited
1984
Highly Cited
1984
Iron-catalyzed hydroxyl radical formation. Stringent requirement for free iron coordination site.
The catalysis by iron of the formation of reactive oxygen species in biological systems has been well documented. In this present… (More)
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Highly Cited
1978
Highly Cited
1978
Non-specific serum iron in thalassaemia: an abnormal serum iron fraction of potential toxicity.
Iron binding in the sera of 35 patients with beta thalassaemia major and intermedia was studied. In patients receiving regular… (More)
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