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Deferoxamine

Known as: Butanediamide, N'-(5-((4-((5-(acetylhydroxyamino)pentyl)amino)-1,4-dioxobutyl)hydroxyamino)pentyl)-N-(5-aminopentyl)-N-hydroxy-, DFOM, Deferoximine 
An iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
The hypoxic response is an ancient stress response triggered by low ambient oxygen (O2) (ref. 1) and controlled by hypoxia… Expand
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Highly Cited
2006
Highly Cited
2006
Most deaths in beta-thalassemia major result from cardiac complications due to iron overload. Differential effects on myocardial… Expand
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Highly Cited
2006
Highly Cited
2006
Deferoxamine (DFO) therapy has been associated with improved survival of thalassemia patients. However, cardiac disease remains… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND AND OBJECTIVES Seven Italian centers reported data on survival, causes of death and appearance of complications in… Expand
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Highly Cited
2003
Highly Cited
2003
Artemisinins are extracted from sweet wormwood (Artemisia annua) and are the most potent antimalarials available, rapidly killing… Expand
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Review
2000
Review
2000
  • Y. Christen
  • The American journal of clinical nutrition
  • 2000
  • Corpus ID: 4461028
Research in the field of molecular biology has helped to provide a better understanding of both the cascade of biochemical events… Expand
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Highly Cited
1994
Highly Cited
1994
BACKGROUND To determine whether deferoxamine prevents the complications of transfusional iron overload in thalassemia major, we… Expand
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Highly Cited
1994
Highly Cited
1994
Hypoxia-inducible factor 1 (HIF-1) activates erythropoietin gene transcription in Hep3B cells subjected to hypoxia. HIF-1… Expand
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Highly Cited
1991
Highly Cited
1991
Endothelial cells, macrophages, neutrophils, and neuronal cells generate superoxide (O2-) and nitric oxide (.NO) which can… Expand
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Highly Cited
1990
Highly Cited
1990
Superoxide dismutase reduces injury in many disease processes, implicating superoxide anion radical (O2-.) as a toxic species in… Expand
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