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Iron, brain ageing and neurodegenerative disorders
TLDR
By studying the accumulation and cellular distribution of iron during ageing, this work should be able to increase the understanding of these neurodegenerative disorders and develop new therapeutic strategies. Expand
The role of iron in brain ageing and neurodegenerative disorders
TLDR
MRI can often identify changes in iron homoeostasis, thus providing a potential diagnostic biomarker of neurodegenerative diseases and an important avenue to reduce iron accumulation is the use of iron chelators that are able to cross the blood-brain barrier, penetrate cells, and reduce excessive iron accumulation, thereby affording neuroprotection. Expand
Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells.
TLDR
The toxicity of iron in specific tissues and cell types (liver, macrophages and brain) is illustrated by studies with appropriate cellular and animal models and the prospects for chelation therapy in the treatment and possible prevention of neurodegenerative diseases is reviewed. Expand
Inorganic Biochemistry of Iron Metabolism: From Molecular Mechanisms to Clinical Consequences
TLDR
The role of Iron-related Genes on the Risk and Outcome of Infection and the Importance of Cytoprotection in Biological Systems are discussed. Expand
Old Iron, Young Copper: from Mars to Venus
TLDR
It is concluded that the early chemistry of life used water soluble ferrous iron while copper was in the water-insoluble Cu(I) state as highly insoluble sulphides, and copper, now bioavailable, was ideally suited to exploit the oxidizing power of dioxygen. Expand
Inorganic biochemistry of iron metabolism
Solution chemistry of iron in biological media the importance of iron for biological systems microbial iron uptake and intracellular release iron assimilation in plants and fungi iron absorption inExpand
Brain iron metabolism and its perturbation in neurological diseases
Enormous advances have been made in the last decade in understanding iron metabolism and iron homeostasis at both the cellular and the systemic level. This includes the identification of genes andExpand
Iron storage in Saccharomyces cerevisiae
TLDR
A study of the intracellular distribution of iron has shown that the vacuoles are involved in the storage of iron in the yeast cell, and it seems that this vacuolar iron can be further utilised by the cells for iron‐requiring processes such as mitochondriogenesis. Expand
Chemistry for an essential biological process: the reduction of ferric iron
TLDR
In a short overview of iron chemistry, some of the pitfalls using standard redox potentials are pointed out, the interaction of ferric complexes with hydrogen peroxide to give hydroxyl radicals are commented on, and the role of dissimilatory ferric reduction in microbial respiration and biomineralization is discussed. Expand
Brain iron metabolism and its perturbation in neurological diseases
TLDR
There is overwhelming evidence for a direct involvement of iron in NDs, with emphasis on recent data linking in particular interactions between iron homeostasis and key disease proteins. Expand
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