Requirement of Caspase-3(-like) Protease-mediated Hydrogen Peroxide Production for Apoptosis Induced by Various Anticancer Drugs*
- S. Simizu, M. Takada, K. Umezawa, M. Imoto
- Biology, ChemistryJournal of Biological Chemistry
- 9 October 1998
Activation of caspase-3(-like) proteases by various anticancer drugs causes generation of H2O2 presumably through the activation of NADPH oxidase, thereby inducing apoptosis, and H1O2 may function as a common mediator for apoptosis induced by various anti-cancer drugs.
Inhibition of RANKL‐Induced Osteoclastogenesis by (−)‐DHMEQ, a Novel NF‐κB Inhibitor, Through Downregulation of NFATc1
- H. Takatsuna, M. Asagiri, K. Umezawa
- Medicine, BiologyJournal of Bone and Mineral Research
- 6 December 2004
(−)‐DHMEQ, a newly designed NF‐κB inhibitor, inhibited RANKL‐induced osteoclast differentiation in mouse BMMs through downregulation of the induction of NFATc1, an essential transcription factor of…
JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and reed-sternberg…
It is found that the CD30 promoter in tumor cells of both nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK)-positive and NPM-ALK-negative ALCL and HL is regulated by a constitutively active CD30-extracellular signal-regulated kinases (ERK) 1/2 mitogen-activated protein kinase(MAPK).
Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model.
- M. Kubota, S. Shimmura, K. Tsubota
- Biology, MedicineInvestigative Ophthalmology and Visual Science
- 21 January 2011
Immediate antioxidant therapy with H2-enriched irrigation solution is a new potent treatment of angiogenesis in cornea to prevent blindness caused by alkali burn.
Synthesis of NF-κB activation inhibitors derived from epoxyquinomicin C
Identification of TIFA as an Adapter Protein That Links Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) to Interleukin-1 (IL-1) Receptor-associated Kinase-1 (IRAK-1) in IL-1 Receptor…
Analysis of endogenous proteins indicates that TIFA associates with TRAF6 constitutively, whereas it associates with IRAK-1 in an IL-1 stimulation-dependent manner in vivo, Thus, TIFA is likely to mediate IRAk-1/TRAF6 interaction upon IL- 1 stimulation.
Neuronal Apoptosis by Apolipoprotein E4 through Low-Density Lipoprotein Receptor-Related Protein and Heterotrimeric GTPases
It is concluded that one of the neurotoxic mechanisms triggered by ApoE4 is to activate a cell type-specific apoptogenic program involving LRP and the Gi class of GTPases and that the apoE 4 gene may play a direct role in the pathogenesis of AD and other forms of dementia.
TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells.
Findings provide direct evidence of the effects of RAW 264.7-derived TNF-α on TGF-β-induced EMT in A549 cells, which is transduced in part by NFκB signalling.
Cyclopentabenzofuran lignan protein synthesis inhibitors from Aglaia odorata.
- T. Ohse, S. Ohba, T. Yamamoto, T. Koyano, K. Umezawa
- Chemistry, BiologyJournal of Natural Products
- 22 July 1996
Aglaiastatin reduced the amount of Ras, possibly by inhibiting its de novo synthesis, and was slightly more potent than 1 and 2 in inhibiting cell growth.