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Requirement of Caspase-3(-like) Protease-mediated Hydrogen Peroxide Production for Apoptosis Induced by Various Anticancer Drugs*
Caspase-3(-like) proteases play important roles in controlling mammalian apoptosis. However, the downstream events from the caspase-3(-like) protease activation to death of cells are still unclear.Expand
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Inhibition of RANKL‐Induced Osteoclastogenesis by (−)‐DHMEQ, a Novel NF‐κB Inhibitor, Through Downregulation of NFATc1
(−)‐DHMEQ, a newly designed NF‐κB inhibitor, inhibited RANKL‐induced osteoclast differentiation in mouse BMMs through downregulation of the induction of NFATc1, an essential transcription factor ofExpand
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Isolation of a novel tyrosine kinase inhibitor, lavendustin A, from Streptomyces griseolavendus.
A potent tyrosine kinase inhibitor, lavendustin A [1], has been isolated from a butyl acetate extract of Streptomyces griseolavendus culture filtrate. It inhibits epidermal growth factorExpand
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Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.
Cellular and plasma fibronectins are heterodimers consisting of similar but not identical polypeptides. The differences between fibronectin subunits are due in part to the variability of internalExpand
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JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and reed-sternberg
High expression of CD30 and JunB is characteristic of tumor cells in anaplastic large cell lymphoma (ALCL) and Hodgkin lymphoma (HL). Possible interactions of CD30 and JunB were examined in thisExpand
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TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells.
Cancer cells undergo epithelial-mesenchymal transition (EMT) during invasion and metastasis. Although transforming growth factor-β (TGF-β) and pro-inflammatory cytokines have been implicated in EMT,Expand
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Identification of TIFA as an Adapter Protein That Links Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) to Interleukin-1 (IL-1) Receptor-associated Kinase-1 (IRAK-1) in IL-1 Receptor
Tumor necrosis factor receptor-associated factor 6 (TRAF6) transduces signals from members of the Toll/interleukin-1 (IL-1) receptor family by interacting with IL-1 receptor-associated kinase-1Expand
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Nitric oxide mediates murine cytomegalovirus-associated pneumonitis in lungs that are free of the virus.
4 wk after intraperitoneal inoculation of 0.2 LD50 (50% lethal dose) of murine cytomegalovirus (MCMV) in adult BALB/c mice, MCMV remained detectable in the salivary glands, but not in the lungs orExpand
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Thrombin may contribute to the pathophysiology of central nervous system injury.
Thrombin has multiple functions, including its function as a key enzyme during blood coagulation and other physiologic activities. We studied brain tissue reactions to thrombin that might be presentExpand
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Inhibition of epidermal growth factor‐induced DNA synthesis by tyrosine kinase inhibitors
We prepared methyl 2,5‐dihydroxycinnamate as a stable analogue of erbstatin, a tyrosine kinase inhibitor. This analogue was about 4 times more stable than erbstatin in calf serum. It inhibitedExpand
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