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Requirement of Caspase-3(-like) Protease-mediated Hydrogen Peroxide Production for Apoptosis Induced by Various Anticancer Drugs*
Activation of caspase-3(-like) proteases by various anticancer drugs causes generation of H2O2 presumably through the activation of NADPH oxidase, thereby inducing apoptosis, and H1O2 may function as a common mediator for apoptosis induced by various anti-cancer drugs. Expand
Inhibition of RANKL‐Induced Osteoclastogenesis by (−)‐DHMEQ, a Novel NF‐κB Inhibitor, Through Downregulation of NFATc1
(−)‐DHMEQ, a newly designed NF‐κB inhibitor, inhibited RANKL‐induced osteoclast differentiation in mouse BMMs through downregulation of the induction of NFATc1, an essential transcription factor ofExpand
JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and reed-sternberg
It is found that the CD30 promoter in tumor cells of both nucleophosmin (NPM)-anaplastic lymphoma kinase (ALK)-positive and NPM-ALK-negative ALCL and HL is regulated by a constitutively active CD30-extracellular signal-regulated kinases (ERK) 1/2 mitogen-activated protein kinase(MAPK). Expand
TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells.
Findings provide direct evidence of the effects of RAW 264.7-derived TNF-α on TGF-β-induced EMT in A549 cells, which is transduced in part by NFκB signalling. Expand
Neuronal Apoptosis by Apolipoprotein E4 through Low-Density Lipoprotein Receptor-Related Protein and Heterotrimeric GTPases
It is concluded that one of the neurotoxic mechanisms triggered by ApoE4 is to activate a cell type-specific apoptogenic program involving LRP and the Gi class of GTPases and that the apoE 4 gene may play a direct role in the pathogenesis of AD and other forms of dementia. Expand
Synthesis of NF-κB activation inhibitors derived from epoxyquinomicin C
In order to develop new inhibitors of NF-κB activation, we designed and synthesized dehydroxymethyl derivatives of epoxyquinomicin C, namely, DHM2EQ and its regioisomer DHM3EQ. These derivatives wereExpand
Macular Pigment Lutein Is Antiinflammatory in Preventing Choroidal Neovascularization
Lutein treatment led to significant suppression of CNV development together with inflammatory processes including NF-&kgr;B activation and subsequent upregulation of inflammatory molecules, providing molecular evidence of potential validity of lutein supplementation as a therapeutic strategy to suppress CNV. Expand
Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia.
The compound isolated from the chloroform extract of the root of Morinda citrifolia induced normal morphology and cytoskeletal structure in K-rasts-NRK cells at the permissive temperature, without changing the amount and localization of Ras. Expand
Cyclopentabenzofuran lignan protein synthesis inhibitors from Aglaia odorata.
Aglaiastatin reduced the amount of Ras, possibly by inhibiting its de novo synthesis, and was slightly more potent than 1 and 2 in inhibiting cell growth. Expand
Inhibition of epidermal growth factor‐induced DNA synthesis by tyrosine kinase inhibitors
Methyl 2,5‐dihydroxycinnamate was shown to delay the S‐phase induction by epidermal growth factor in quiescent normal rat kidney cells, without affecting the total amount ofDNA synthesis. Expand