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Interleukin-4

Known as: BSF1 (B cell stimulating factor 1), BCGF, interleukin-4 (IL-4) 
A soluble factor produced by activated T-LYMPHOCYTES that induces the expression of MHC CLASS II GENES and FC RECEPTORS on B-LYMPHOCYTES and causes… 
National Institutes of Health

Related topics

Related topics

29 relations

Broader (5)

Antineoplastic AgentsAntirheumatic AgentsHematopoietic Cell Growth FactorsImmunologic Adjuvants
B-CELL GROWTH FACTORHistocompatibility Antigens Class IIIL4 geneIn Blood

Narrower (6)

DAB(389)-interleukin 4Ph8 peptideRecombinant Interleukin-4interleukin-4, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1998
Highly Cited
1998
The IL-4 rapidly produced in BALB/c mice after infection with Leishmania major down-regulates IL-12 receptor beta 2-chain expression on CD4+ T cells resulting in a state of unresponsiveness to IL-12.
Within 1 day of infection with Leishmania major, susceptible BALB/c mice produce a burst of IL-4 in their draining lymph nodes… 
Highly Cited
1997
Highly Cited
1997
Immunoregulatory role of IL-10 during superantigen-induced hyporesponsiveness in vivo.
Injection of the superantigen staphylococcal enterotoxin A (SEA) to mice rapidly elicits production of the Th1-related pro… 
Highly Cited
1997
Highly Cited
1997
Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness.
Previous results have documented a burst of IL-4 mRNA that peaks in draining lymph nodes of susceptible BALB/c mice 16 h after… 
Highly Cited
1996
Highly Cited
1996
IL-13 induces phosphorylation and activation of JAK2 Janus kinase in human colon carcinoma cell lines: similarities between IL-4 and IL-13 signaling.
We have recently reported that IL-13R may share a component with IL-4R. Here we report that both IL-4 and IL-13 share signaling… 
Review
1995
Review
1995
Immune Responses of IL‐4, IL‐5, IL‐6 Deficient Mice
Cytokines are the principal soluble regulators of the immune system and the hematopoietic system (Paul & Seder 1994). In vivo… 
Highly Cited
1995
Highly Cited
1995
Immunological markers indicating the effectiveness of pharmacological treatment in human hydatid disease
The relation of interferon‐gamma (IFN‐γ), IL‐4, IL‐10 production and specific IgE, total IgG, IgG subclass expression to the… 
Highly Cited
1995
Highly Cited
1995
Both Interleukin 4 and Interleukin 13 Induce Tyrosine Phosphorylation of the 140-kDa Subunit of the Interleukin 4 Receptor (*)
We have investigated tyrosine phosphorylation of cellular proteins induced by interleukin (IL) 4 and compared it with the effects… 
Highly Cited
1994
Highly Cited
1994
IL-4 treatment of small splenic B cells induces costimulatory molecules B7-1 and B7-2.
IL-4 has been shown to be involved in the early stages of B cell maturation. Changes induced by IL-4 include cell enlargement… 
Highly Cited
1991
Highly Cited
1991
Molecular cloning of rat interleukin 4 cDNA and analysis of the cytokine repertoire of subsets of CD4+ T cells
Rat peripheral CD4+ T cells may be subdivided into two functionally distinct subpopulations (OX‐22highCD4+ and OX‐22lowCD4+) on… 
Highly Cited
1990
Highly Cited
1990
IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production.
Utilizing a sensitive and selective assay for IL-4, it was shown that lymph node T cells from naive mice could produce small… 
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