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Down-regulation of the macrophage lineage through interaction with OX2 (CD200).
OX2 (CD200) is a broadly expressed membrane glycoprotein, shown here to be important for regulation of the macrophage lineage. In mice lacking CD200, macrophage lineage cells, including brain… Expand
CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression
- P. Kirk, M. Wilson, C. Heddle, M. Brown, A. Barclay, A. Halestrap
- Biology, Medicine
- The EMBO journal
- 1 August 2000
CD147 is a broadly expressed plasma membrane glycoprotein containing two immunoglobulin‐like domains and a single charge‐containing transmembrane domain. Here we use co‐immunoprecipitation and… Expand
The immunoglobulin superfamily--domains for cell surface recognition.
When Ig chains were first sequenced, segments within the constant regions of H and L chains showed sequence similarities, and this led to the idea that the Ig chains had all evolved from a primordial… Expand
Characterization of the CD200 Receptor Family in Mice and Humans and Their Interactions with CD200 1
- G. Wright, H. Cherwinski, +12 authors A. Barclay
- Biology, Medicine
- The Journal of Immunology
- 15 September 2003
CD200 (OX2) is a broadly distributed cell surface glycoprotein that interacts with a structurally related receptor (CD200R) expressed on rodent myeloid cells and is involved in regulation of… Expand
Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.
The OX2 membrane glycoprotein (CD200) is expressed on a broad range of tissues including lymphoid cells, neurons, and endothelium. We report the characterization of an OX2 receptor (OX2R) that is a… Expand
CD200 and membrane protein interactions in the control of myeloid cells.
OX2 (now designated CD200) is a membrane protein expressed by a broad range of cell types. It is the ligand for a receptor restricted to myeloid cells, with the potential to deliver inhibitory… Expand
Human 6-sulfo LacNAc-expressing dendritic cells are principal producers of early interleukin-12 and are controlled by erythrocytes.
Early and high-level production of IL-12 is crucial for effective immune responses against pathogens. Up until now, the cells providing this initial IL-12 have remained elusive. Here we show that a… Expand
Essential Roles for Dok2 and RasGAP in CD200 Receptor-Mediated Regulation of Human Myeloid Cells1
The CD200 receptor (CD200R) acts as a negative regulator of myeloid cells by interacting with its widely expressed ligand CD200. Using mutants expressed in U937 cells, we show that inhibition is… Expand
The SIRP family of receptors and immune regulation
The immune system must be highly regulated to obtain optimal immune responses for the elimination of pathogens without causing undue side effects. This tight regulation involves complex interactions… Expand
CD134L Expression on Dendritic Cells in the Mesenteric Lymph Nodes Drives Colitis in T Cell-Restored SCID Mice1
Transfer of CD45RBhigh CD4+ T cells to immune-deficient mice in the absence of regulatory T cells leads to a Th1-mediated colitis. In this study, we show that intestinal inflammation is characterized… Expand