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Down-regulation of the macrophage lineage through interaction with OX2 (CD200).
In diverse tissues OX2 delivers an inhibitory signal for the macrophage lineage, and outside the brain, disruption of CD200-CD200 receptor interaction precipitated susceptibility to collagen-induced arthritis in mice normally resistant to this disease.
CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression
- P. Kirk, M. Wilson, C. Heddle, M.H. Brown, A. Barclay, A. Halestrap
- BiologyThe EMBO journal
- 1 August 2000
It is concluded that CD147 facilitates proper expression of MCT1 and MCT4 at the cell surface, where they remain tightly bound to each other, and may also be important in determining their activity and location.
The immunoglobulin superfamily--domains for cell surface recognition.
The domain hypothesis was firmly established when the structures of V and C domains were determined to reveal a common fold forming a sandwich of two p-sheets that was stabilized by the conserved disulfide bond.
Characterization of the CD200 Receptor Family in Mice and Humans and Their Interactions with CD200 1
The first characterization of human CD200R (hCD200R) is reported and its binding characteristics to hCD200 are defined, and two mCD200 receptor-like family members were shown to pair with the activatory adaptor protein, DAP12, suggesting that these receptors would transmit strong activating signals in contrast to the apparent inhibitory signal delivered by triggering the CD 200R.
A critical function for CD200 in lung immune homeostasis and the severity of influenza infection
It is demonstrated here that airway macrophages had higher expression of the negative regulator CD200 receptor (CD200R) than did their systemic counterparts and were restrained by CD200 expressed on airway epithelium, which limits inflammatory amplitude and duration during pulmonary influenza infection.
Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function.
CD200 and membrane protein interactions in the control of myeloid cells.
Essential Roles for Dok2 and RasGAP in CD200 Receptor-Mediated Regulation of Human Myeloid Cells1
It is concluded that CD200R inhibits the activation of human myeloid cells through direct recruitment of Dok2 and subsequent activation of RasGAP, which distinguishes this receptor from the majority of inhibitory receptors that utilize ITIMs and recruit phosphatases.
Human 6-sulfo LacNAc-expressing dendritic cells are principal producers of early interleukin-12 and are controlled by erythrocytes.
The SIRP family of receptors and immune regulation
This Review describes recent studies defining the ligands of the SIRP-family members, with particular emphasis on relating the molecular interactions of these proteins to their role in immune-cell regulation.