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Insulin-Like Growth-Factor-Binding Proteins

Known as: IGF Binding Proteins, Somatomedin Binding Proteins, Insulin-Like Growth Factor Binding Proteins 
A family of soluble proteins that bind insulin-like growth factors and modulate their biological actions at the cellular level. Serum IGFBP levels… 
National Institutes of Health

Related topics

Related topics

17 relations

Broader (1)

Binding Proteins
IGFBPL1 geneIn BloodInsulin-like growth factor binding protein 3:PrThr:Pt:Urine:OrdLigand Binding

Narrower (3)

Kazald1 protein, mouseacid-labile subunit, Drosophilainsulin-like growth factor binding protein-related protein 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2012
Review
2012
Insulin-Like Growth Factor Binding Proteins: A Structural Perspective
Insulin-like growth factor binding proteins (IGFBP-1 to -6) bind insulin-like growth factors-I and -II (IGF-I and IGF-II) with… 
Highly Cited
2011
Highly Cited
2011
Evolution of the insulin-like growth factor binding protein (IGFBP) family.
The evolution of the IGF binding protein (IGFBP) gene family has been difficult to resolve. Both chromosomal and serial… 
Highly Cited
2006
Highly Cited
2006
Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins
Insulin-like growth factor-binding proteins (IGFBPs) control bioavailability, activity, and distribution of insulin-like growth… 
Highly Cited
2004
Highly Cited
2004
EWS/FLI-1 Silencing and Gene Profiling of Ewing Cells Reveal Downstream Oncogenic Pathways and a Crucial Role for Repression of Insulin-Like Growth Factor Binding Protein 3
ABSTRACT Ewing tumors are characterized by abnormal transcription factors resulting from the oncogenic fusion of EWS with members… 
Highly Cited
2004
Highly Cited
2004
Insulin-like growth factor-binding protein 5 (Igfbp5) compromises survival, growth, muscle development, and fertility in mice
The insulin-like growth factors (IGFs) are essential for development; bioavailable IGF is tightly regulated by six related IGF… 
Highly Cited
2000
Highly Cited
2000
Plasma insulin-like growth factor (IGF) I, IGF-binding protein 3, and mammographic density.
Insulin-like growth factors (IGFs) and insulin-like growth factor-binding proteins (IGFBPs) play a role in the normal development… 
Review
2000
Review
2000
Regulation of ovarian follicular growth by somatotropin and insulin-like growth factors in cattle.
Somatotropin (ST), insulin-like growth factor (IGF)-I, and IGF-II affect animal growth and lactation as well as animal… 
Highly Cited
1996
Highly Cited
1996
Critical illness is associated with low circulating concentrations of insulin-like growth factors-I and -II, alterations in insulin-like growth factor binding proteins, and induction of an insulin…
OBJECTIVES To describe the sequential changes in the circulating concentrations of insulin-like growth factor-I, insulin-like… 
Highly Cited
1994
Highly Cited
1994
Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes.
The mechanisms by which insulin-like growth factor-I (IGF-I) is released from insulin-like growth factor binding proteins (IGFBPs… 
Highly Cited
1993
Highly Cited
1993
Elevated levels of insulin-like growth factor-binding protein-2 in the serum of prostate cancer patients.
We have previously documented the presence of specific insulin-like growth factor (IGF)-binding protein (IGFBPs) in seminal… 
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