• Publications
  • Influence
XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY, and pancreatic polypeptide receptors.
TLDR
Based on structural and evolutionary criteria, neuropeptide Y (NPY)b, peptide YY (PYY) and pancreatic polypetide (PP) are closely related polypeptides that share considerable amino acid homology, amidated C-terminal ends, and the same structure. Expand
Evolution of neuropeptide Y, peptide YY and pancreatic polypeptide
  • D. Larhammar
  • Medicine, Biology
  • Regulatory Peptides
  • 9 April 1996
TLDR
In bony and cartilaginous fishes, NPY and PYY have only 5-6 differences which, together with more extensive neuronal localization of PYY, indicate an even greater functional overlap between the two peptides in these animal groups. Expand
Cloning of a Human Receptor of the NPY Receptor Family with High Affinity for Pancreatic Polypeptide and Peptide YY (*)
TLDR
In stably transfected Chinese hamster ovary cells the PP1 receptor inhibits forskolin-stimulated cAMP synthesis and is named PP1 because these data may identify the receptor as primarily a PP receptor. Expand
Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type.
TLDR
Northern blot analysis of a human neuroblastoma cell line, SK-N-MC, revealed a single 3.5-kilobase mRNA species, supporting the view that the Y1 receptor is associated with NPY/PYY-evoked vasoconstriction. Expand
General and Comparative Endocrinology
ING AND INDEXING
Evolution of the neuropeptide Y family: new genes by chromosome duplications in early vertebrates and in teleost fishes.
TLDR
The analyses support origin of NPY and peptide YY (PYY) from a common ancestor in early vertebrate evolution through a chromosome duplication and shows that when sequence comparisons give ambiguous results, chromosomal location can serve as a useful criterion to identify orthologs. Expand
Vertebrate genome evolution and the zebrafish gene map
18, 345–349 (1998).
Neuropeptide-Y gene expression in the goldfish brain: distribution and regulation by ovarian steroids.
TLDR
This report represents the first study on NPY gene expression in a nonmammalian species and demonstrates that 1) NPY mRNA is present in the neuroendocrine regulatory centers; and 2) ovarian steroids stimulate NPYGene expression in the POA. Expand
Evolution of vertebrate rod and cone phototransduction genes
TLDR
No less than 10 of the 13 studied phototransduction gene families received additional members in the two basal vertebrate tetraploidizations, and the implications of the many early vertebrate gene duplications for functional specialization of specific retinal cell types, particularly cones and rods are discussed. Expand
Extensive duplications of phototransduction genes in early vertebrate evolution correlate with block (chromosome) duplications.
TLDR
It is concluded that gene duplications in early vertebrate evolution probably helped facilitate the specialization of the retina and the subspecialization of different retinal cell types. Expand
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