• Publications
  • Influence
Prostate-Specific Antigen as a Serum Marker for Adenocarcinoma of the Prostate
TLDR
PSA is more sensitive than PAP in the detection of prostatic cancer and will probably be more useful in monitoring responses and recurrence after therapy, however, since both PSA and PAP may be elevated in benign prostatic hyperplasia, neither marker is specific. Expand
Random systematic versus directed ultrasound guided transrectal core biopsies of the prostate.
TLDR
Ultrasound guided random systematic biopsy provides a highly accurate means to diagnose prostate cancer, minimizing observer and sampling errors and providing valuable additional information on cancer volume, Gleason grade and the potential location of surgically positive margins, all without compromising the operation or the chance for a surgical cure. Expand
Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate.
TLDR
PSA is more sensitive than PAP in the detection of prostatic cancer and will probably be more useful in monitoring responses and recurrence after therapy, however, since both PSA and PAP may be elevated in benign prostatic hyperplasia, neither marker is specific. Expand
Localized prostate cancer. Relationship of tumor volume to clinical significance for treatment of prostate cancer
TLDR
The authors calculated the probability at birth of having a diagnosis of prostate cancer within a man's life to be 8.8% and subtracted the incidence of microscopic Stage A cancers too small to ever be clinically significant. Expand
Zonal Distribution of Prostatic Adenocarcinoma: Correlation with Histologic Pattern and Direction of Spread
TLDR
It is concluded that carcinoma typically arises in the region of the prostate that is susceptible to benign prostatic hyperplasia and that the great majority of Stage A (TUR) cancers are transition zone cancers. Expand
Biological determinants of cancer progression in men with prostate cancer.
TLDR
The % Gleason grade 4/5, cancer volume, positive lymph node findings, and intraprostatic vascular invasion were independently associated with prostate cancer progression, defined by an increasing PSA level. Expand
RS-17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha, alpha-dimethyl-1H-indole-3-ethanamine hydrochloride), a selective alpha 1A-adrenoceptor antagonist, displays low affinity for
TLDR
Findings indicate that contractile responses to NE in human LUT tissues are mediated by a receptor displaying pharmacological properties that are clearly different from those of the defined alpha 1A-adrenoceptor and raise the possibility that multiple forms of the alpha 1a-adRenoceptor may exist inhuman LUT that are discriminated by RS-17053. Expand
The prostate specific antigen era in the United States is over for prostate cancer: what happened in the last 20 years?
TLDR
Serum PSA was related to prostate cancer 20 years ago but in the last 5 years serum PSA has only been related to benign prostatic hyperplasia and there is an urgent need for serum markers that reflect the size and grade of this ubiquitous cancer. Expand
Multiple cancers in the prostate. Morphologic features of clinically recognized versus incidental tumors
TLDR
It was concluded that additional incidental tumors are common in patients with prostate cancer, but their sum of volumes is seldom as large as the clinical cancer volume. Expand
...
1
2
3
4
5
...