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Prostate-Specific Antigen as a Serum Marker for Adenocarcinoma of the Prostate
PSA is more sensitive than PAP in the detection of prostatic cancer and will probably be more useful in monitoring responses and recurrence after therapy, however, since both PSA and PAP may be elevated in benign prostatic hyperplasia, neither marker is specific.
Random systematic versus directed ultrasound guided transrectal core biopsies of the prostate.
Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate.
Bacteriologic localization patterns in bacterial prostatitis and urethritis.
Zonal Distribution of Prostatic Adenocarcinoma: Correlation with Histologic Pattern and Direction of Spread
- J. McNeal, E. Redwine, F. Freiha, T. Stamey
- MedicineThe American journal of surgical pathology
- 1 December 1988
It is concluded that carcinoma typically arises in the region of the prostate that is susceptible to benign prostatic hyperplasia and that the great majority of Stage A (TUR) cancers are transition zone cancers.
Localized prostate cancer. Relationship of tumor volume to clinical significance for treatment of prostate cancer
The authors calculated the probability at birth of having a diagnosis of prostate cancer within a man's life to be 8.8% and subtracted the incidence of microscopic Stage A cancers too small to ever be clinically significant.
RS-17053 (N-[2-(2-cyclopropylmethoxyphenoxy)ethyl]-5-chloro-alpha, alpha-dimethyl-1H-indole-3-ethanamine hydrochloride), a selective alpha 1A-adrenoceptor antagonist, displays low affinity for…
Findings indicate that contractile responses to NE in human LUT tissues are mediated by a receptor displaying pharmacological properties that are clearly different from those of the defined alpha 1A-adrenoceptor and raise the possibility that multiple forms of the alpha 1a-adRenoceptor may exist inhuman LUT that are discriminated by RS-17053.
Biological determinants of cancer progression in men with prostate cancer.
The % Gleason grade 4/5, cancer volume, positive lymph node findings, and intraprostatic vascular invasion were independently associated with prostate cancer progression, defined by an increasing PSA level.
The prostate specific antigen era in the United States is over for prostate cancer: what happened in the last 20 years?
- T. Stamey, M. Caldwell, J. McNeal, R. Nolley, Marci Hemenez, Joshua Downs
- MedicineThe Journal of urology
- 1 October 2004
Serum PSA was related to prostate cancer 20 years ago but in the last 5 years serum PSA has only been related to benign prostatic hyperplasia and there is an urgent need for serum markers that reflect the size and grade of this ubiquitous cancer.