R. Huber

Publications1,192
h-index149
Citations85,569
Highly Influential Citations3,150
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Accurate Bond and Angle Parameters for X-ray Protein Structure Refinement
Bond-length and bond-angle parameters are derived from a statistical survey of X-ray structures of small compounds from the Cambridge Structural Database. The side chains of the common amino acids…
Structure of 20S proteasome from yeast at 2.4Å resolution
TLDR
Two β-type subunits are processed to an intermediate form, indicating that an additional nonspecific endopeptidase activity may exist which is important for peptide hydrolysis and for the generation of ligands for class I molecules of the major histocompatibility complex.
Thermotoga maritima sp. nov. represents a new genus of unique extremely thermophilic eubacteria growing up to 90°C
TLDR
A novel type of bacterium has been isolated from various geothermally heated locales on the sea floor with a unique sheath-like structure and monotrichous flagellation that clearly belong to the eubacteria, although no close relationship to any known group could be detected.
Crystal structure of the 20S proteasome from the archaeon T. acidophilum at 3.4 A resolution.
The three-dimensional structure of the proteasome from the archaebacterium Thermoplasma acidophilum has been elucidated by x-ray crystallographic analysis by means of isomorphous replacement and…
The genome sequence of the extreme thermophile Thermus thermophilus
TLDR
The complete genome sequence of T. thermophilus HB27 is presented, the first for the genus Thermus and candidates include various proteases and key enzymes of other fundamental biological processes such as DNA replication, DNA repair and RNA maturation.
Crystal structure of DegP (HtrA) reveals a new protease-chaperone machine
TLDR
The crystal structure of DegP, a widely conserved heat shock protein that combines refolding and proteolytic activities, is solved and the chaperone conformation is solved, in which substrate binding in addition to catalysis is abolished.
Crystal Structure of the Thermosome, the Archaeal Chaperonin and Homolog of CCT
Structural analysis of human IgG-Fc glycoforms reveals a correlation between glycosylation and structural integrity.
The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium.
TLDR
Calpains (calcium-dependent cytoplasmic cysteine proteinases) are implicated in processes such as cytoskeleton remodeling and signal transduction and could also mediate membrane binding, thereby explaining calpains' strongly reduced calcium requirements in vivo.
The complete genome of the hyperthermophilic bacterium Aquifex aeolicus
TLDR
The complete genome sequence of A. aeolicus is described, consisting of 1,551,335 base pairs, and it is shown that the use of oxygen (albeit at very low concentrations) as an electron acceptor is allowed by the presence of a complex respiratory apparatus.
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