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Immunoglobulin Idiotypes

Known as: Idiotype, Immunoglobulin, Idiotype, idiotypes 
Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody… 
National Institutes of Health

Related topics

Related topics

6 relations
Antibodies, Anti-IdiotypicIn Bloodaspects of radiation effectsphysiological aspects

Broader (2)

ImmunoglobulinsImmunologic Factors

Papers overview

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Highly Cited
1996
Highly Cited
1996
Vaccination with syngeneic, lymphoma-derived immunoglobulin idiotype combined with granulocyte/macrophage colony-stimulating factor primes mice for a protective T-cell response.
The idiotype of the Ig expressed by a B-cell malignancy (Id) can serve as a unique tumor-specific antigen and as a model for… 
Highly Cited
1989
Highly Cited
1989
Evidence for a functional idiotypic network among natural antibodies in normal mice.
We monitored in normal adult BALB/c mice the serum concentrations of four natural IgM antibodies, two of which show idiotypic… 
Highly Cited
1986
Highly Cited
1986
Idiotype‐Directed Interactions during Ontogeny Play a Major Role in the Establishment of the Adult B Cell Repertoire
IgM hybridomas derived from perinatal B cells show a high degree of auto-reactivity and many had demonstrable anti-idiotypic… 
Highly Cited
1982
Highly Cited
1982
Autoantibodies to insulin receptor spontaneously develop as anti-idiotypes in mice immunized with insulin.
Mice immunized with insulin developed antibodies to both insulin and the insulin receptor. The antibodies to insulin receptor… 
Highly Cited
1982
Highly Cited
1982
Anti-DNA autoantibodies in (NZB X NZW)F1 mice are clonally heterogeneous, but the majority share a common idiotype.
Monoclonal anti-DNA antibodies from 13 cloned hybridoma cell lines have been used to analyze the clonal heterogeneity of… 
Highly Cited
1978
Highly Cited
1978
Recognition of idiotypes in lymphocyte interactions II. Antigen‐independent cooperation between T and B lymphocytes that possess similar and complementary idiotypes
Antigen‐independent cooperation between T and B lymphocytes is demonstrated in vitro in two different experimental protocols: (a… 
Review
1977
Review
1977
Idiotypes as Variable Region Markers Analogies between Receptors on Phosphorylcholine‐Specific T and B Lymphocytes
B ceU(s): bone marrow-derived cells; T cell(s): thymus-derived cells; Ig: immuno^ globulin; V-region: variable region; Ir genes… 
Highly Cited
1974
Highly Cited
1974
Large numbers of cells in normal mice produce antibody components of isologous erythrocytes
THERE are a number of arguments against the idea1 that self-tolerance depends on a purge of all self-reactive clones early in… 
Highly Cited
1974
Highly Cited
1974
INHERITANCE OF ANTIBODY SPECIFICITY
Our data suggest that fine specificity of antihapten antibodies is a useful Mendelian marker of variable (V) genes. We found that… 
Highly Cited
1972
Highly Cited
1972
Idiotypic identity of antibodies to streptococcal carbohydrate in inbred mice
In this study antibodies to the streptococcal carbohydrate of inbred strains of mice were investigated for the occurrence of… 
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