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Immunoglobulin Idiotypes

Known as: Idiotype, Immunoglobulin, Idiotype, idiotypes 
Unique genetically-controlled determinants present on ANTIBODIES whose specificity is limited to a single group of proteins (e.g., another antibody… 
National Institutes of Health

Related topics

Related topics

6 relations
Antibodies, Anti-IdiotypicIn Bloodaspects of radiation effectsphysiological aspects

Broader (2)

ImmunoglobulinsImmunologic Factors

Papers overview

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Highly Cited
1998
Highly Cited
1998
Idiotype immunization combined with granulocyte-macrophage colony-stimulating factor in myeloma patients induced type I, major histocompatibility complex-restricted, CD8- and CD4-specific T-cell…
Idiotypic structures expressed on the myeloma Ig protein might be regarded as a tumor-specific antigen. Five patients with IgG… 
Highly Cited
1990
Highly Cited
1990
Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation
The proximate cause of autoantibodies characteristic of systemic autoimmune diseases has been controversial. One hypothesis is… 
Review
1990
Review
1990
Three-dimensional structure of an idiotope–anti-idiotope complex
SEROLOGICALLY detected antigenic determinants unique to an antibody or group of antibodies1–3 are called idiotopes. The sum of… 
Highly Cited
1989
Highly Cited
1989
Treatment of B-cell lymphomas with anti-idiotype antibodies alone and in combination with alpha interferon.
Idiotypes are distinct clonal markers for B-cell lymphomas. Previously we reported the use of anti-idiotype antibodies in the… 
Highly Cited
1985
Highly Cited
1985
Emergence of idiotype variants during treatment of B-cell lymphoma with anti-idiotype antibodies.
We studied two patients with malignant B-cell lymphoma that manifested resistance to the therapeutic effects of anti-idiotype… 
Highly Cited
1982
Highly Cited
1982
Anti-phosphorylcholine antibodies of the T15 idiotype are optimally protective against Streptococcus pneumoniae
In the mouse, most anti-PC antibody is found in one of the three murine anti-PC idiotype families: T15, M603, or M511. The… 
Highly Cited
1980
Highly Cited
1980
Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangments in heavy chain V-region gene segments
The complete variable region sequences from ten antibodies and two myeloma proteins binding α-1,3 dextran have been determined… 
Review
1978
Review
1978
Expression and function of idiotypes of lymphocytes.
Highly Cited
1975
Highly Cited
1975
Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. I. Demonstration of similar or identical idiotypes on IgG molecules and T-cell receptors with…
Antigen-binding receptors on T lymphocytes and IgG antibodies with the same antigen-binding specificity as the T-cell receptors… 
Review
1974
Review
1974
GENETICS OF A NEW IgVH (T15 IDIOTYPE) MARKER IN THE MOUSE REGULATING NATURAL ANTIBODY TO PHOSPHORYLCHOLINE
The idiotype present on the Fab of a phosphorylcholine-binding IgA myeloma protein TEPC 15 (T15) of BALB/c origin was found in… 
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