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- Publications
- Influence
Diversity of PspA: Mosaic Genes and Evidence for Past Recombination in Streptococcus pneumoniae
- S. Hollingshead, R. Becker, D. Briles
- Biology, Medicine
- Infection and Immunity
- 1 October 2000
ABSTRACT Pneumococcal surface protein A (PspA) is a serologically variable protein of Streptococcus pneumoniae. Twenty-four diverse alleles of the pspA gene were sequenced to investigate the genetic… Expand
The pspC Gene of Streptococcus pneumoniae Encodes a Polymorphic Protein, PspC, Which Elicits Cross-Reactive Antibodies to PspA and Provides Immunity to Pneumococcal Bacteremia
- A. Brooks-Walter, D. Briles, S. Hollingshead
- Biology, Medicine
- Infection and Immunity
- 1 December 1999
ABSTRACT PspC is one of three designations for a pneumococcal surface protein whose gene is present in approximately 75% of allStreptococcus pneumoniae strains. Under the name SpsA, the protein has… Expand
Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 streptococcus pneumoniae
- D. Briles, M. Nahm, +4 authors R. Barletta
- Medicine
- The Journal of experimental medicine
- 1 March 1981
The antiphosphocholine (PC) antibody in normal mouse sera (NMS) provides protection against intravenous infection with encapsulated strain WU2 of type 3 Streptococcus pneumoniae. Mice unable to make… Expand
Basophils enhance immunological memory responses
- Andrea Denzel, U. Maus, +9 authors M. Mack
- Chemistry, Medicine
- Nature Immunology
- 1 July 2008
The cellular basis of immunological memory remains a controversial issue. Here we show that basophils bound large amounts of intact antigens on their surface and were the main source of interleukins… Expand
Mn2+-Dependent Regulation of Multiple Genes in Streptococcus pneumoniae through PsaR and the Resultant Impact on Virulence
- J. W. Johnston, D. Briles, Lisa E. Myers, S. Hollingshead
- Biology, Medicine
- Infection and Immunity
- 1 February 2006
ABSTRACT The concentration of Mn2+ is 1,000-fold higher in secretions than it is at internal sites of the body, making it a potential signal by which bacteria can sense a shift from a mucosal… Expand
Reduced virulence of a defined pneumolysin-negative mutant of Streptococcus pneumoniae.
- A. M. Berry, J. Yother, D. Briles, D. Hansman, J. Paton
- Biology, Medicine
- Infection and immunity
- 1 July 1989
Insertion-duplication mutagenesis was used to construct a pneumolysin-negative derivative of Streptococcus pneumoniae. This was achieved by first transforming the nonencapsulated strain Rx1 with a… Expand
Role of Pneumococcal Surface Protein C in Nasopharyngeal Carriage and Pneumonia and Its Ability To Elicit Protection against Carriage of Streptococcus pneumoniae
- P. Balachandran, A. Brooks-Walter, A. Virolainen-Julkunen, S. Hollingshead, D. Briles
- Biology, Medicine
- Infection and Immunity
- 1 May 2002
ABSTRACT Previous studies suggested that PspC is important in adherence and colonization within the nasopharynx. In this study, we conducted mutational studies to further identify the role PspC plays… Expand
Lipoprotein PsaA in Virulence of Streptococcus pneumoniae: Surface Accessibility and Role in Protection from Superoxide
- J. W. Johnston, Lisa E. Myers, Martina M. Ochs, W. Benjamin, D. Briles, S. Hollingshead
- Biology, Medicine
- Infection and Immunity
- 1 October 2004
ABSTRACT PsaA of Streptococcus pneumoniae, originally believed to be an adhesin, is the lipoprotein component of an Mn2+ transporter. Mutations in psaA cause deficiencies in growth, virulence,… Expand
Subclass restriction of murine anti-carbohydrate antibodies.
- R. Perlmutter, D. Hansburg, D. Briles, R. A. Nicolotti, J. Davie
- Biology, Medicine
- Journal of immunology
- 1 August 1978
Examination of the subclass distribution of murine antibodies directed against groups A and C streptococcal carbohydrate, alpha-(1 leads to 3) dextran and phosphocholine yields the surprising… Expand
Intranasal Immunization of Mice with a Mixture of the Pneumococcal Proteins PsaA and PspA Is Highly Protective against Nasopharyngeal Carriage of Streptococcus pneumoniae
- D. Briles, E. Ades, +6 authors S. Hollingshead
- Biology, Medicine
- Infection and Immunity
- 1 February 2000
ABSTRACT Acquisition of pneumococci is generally from carriers rather than from infected individuals. Therefore, to induce herd immunity againstStreptococcus pneumoniae it will be necessary to elicit… Expand