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AC133, a novel marker for human hematopoietic stem and progenitor cells.
AC133 is one of a new panel of murine hybridoma lines producing monoclonal IgG antibodies (mAbs) to a novel stem cell glycoprotein antigen with a molecular weight of 120 kD. AC133 antigen is… Expand
Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens.
The rate of pathogen elimination determines the extent and consequences of an infection. In this context, the spleen with its highly specialized lymphoid compartments plays a central role in clearing… Expand
Marginal-zone B cells
Recent advances in genomics and proteomics, combined with the facilitated generation and analysis of transgenic and gene-knockout animals, have revealed new complexities in classical biological… Expand
PI3 Kinase Signals BCR-Dependent Mature B Cell Survival
Previous work has shown that mature B cells depend upon survival signals delivered to the cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal, we have… Expand
Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas
A rat monoclonal antibody specific for immunoglobulin (Ig) heavy chain binding protein (BiP) has allowed the examination of the association of BiP with assembling Ig precursors in mouse B… Expand
Identification of the immunodominant protein and other proteins of the Bacillus anthracis exosporium.
- Christopher T Steichen, P. Chen, J. Kearney, C. L. Turnbough
- Medicine, Biology
- Journal of bacteriology
- 15 March 2003
Spores of Bacillus anthracis, the causative agent of anthrax, are enclosed by a prominent loose-fitting, balloon-like layer called the exosporium. Although the exosporium serves as the source of… Expand
Marginal zone B cells exhibit unique activation, proliferative and immunoglobulin secretory responses.
- A. Oliver, F. Martin, G. Gartland, R. Carter, J. Kearney
- Medicine, Biology
- European journal of immunology
- 1 September 1997
Mouse splenic B cells can be separated based on their distinctive expression of cell surface antigens. Marginal zone (MZ) B cells are CD38high CD21high CD23low/-, while follicular (FO) B cells are… Expand
IgMhighCD21high lymphocytes enriched in the splenic marginal zone generate effector cells more rapidly than the bulk of follicular B cells.
Ag encounter will recruit Ag-specific cells from the pool of mature B lymphocytes in the spleen and activate them to perform effector functions: generation of Ab-forming cells (plasma cells) and… Expand
Autoreactivity by design: innate B and T lymphocytes
Innate B and T lymphocytes are a subset of lymphocytes that express a restricted set of semi-invariant, germ-line-encoded, autoreactive antigen receptors. Although they have long been set apart from… Expand
Positive selection from newly formed to marginal zone B cells depends on the rate of clonal production, CD19, and btk.
Using immunoglobulin heavy chain transgenic mice, we show that B cell clones reaching the long-lived pool are heterogeneous: some are enriched in the CD21(high) compartment (mostly marginal zone… Expand