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Recent primary toxoplasma infection indicated by a low avidity of specific IgG.
- K. Hedman, M. Lappalainen, I. Seppäiä, O. Mäkelä
- Medicine, BiologyThe Journal of infectious diseases
- 1 April 1989
An unusual IgG avidity assay was developed for the serologic diagnosis of recent primary infection by Toxoplasma gondii and may be used to identify pregnancies that are at risk for congenital toxoplasmosis.
Evaluation of CA 19-9 as a serum tumour marker in pancreatic cancer.
- C. Haglund, P. Roberts, P. Kuusela, T. Scheinin, O. Mäkelä, H. Jalanko
- Medicine, BiologyBritish Journal of Cancer
- 1 February 1986
Preliminary results suggest that the CA 19-9 assay can be used in the monitoring of surgically treated patients and can be useful as an additional diagnostic tool for the detection of pancreatic cancer.
Anti-oxazolone hybridomas and the structure of the oxazolone idiotype.
Antibodies raised in several mouse and rat strains against the hapten 2-phenyloxazolone (phOx) regularly contain a fraction recognized by antiidiotypic reagents, which is studied by generating over fifty anti-phOx antibody-secreting hybridoma clones.
Comparison of CA 19-9 and carcinoembryonic antigen (CEA) levels in the serum of patients with colorectal diseases.
The sensitivity of the CA 19-9 test (36%) was poorer than that of the CEA assay (69%), but the new test was markedly more specific (97% vs 70%) than theCEA assay.
A mendelian idiotype is demonstrable in the heteroclitic anti‐NP antibodies of the mouse
It is shown that three mouse strains of allotype b produce a restricted response to hapten, and studies with a guinea pig anti‐idiotype serum which recognized the products of the VHNPb gene but not other Ig showed that Binding of idiotype NP‐b was haptan‐inhibitable.
Isotype concentrations of human antibodies to Haemophilus influenzae type b polysaccharide (Hib) in young adults immunized with the polysaccharide as such or conjugated to a protein (diphtheria…
- O. Mäkelä, P. Mattila, N. Rautonen, I. Seppälä, J. Eskola, H. Käyhty
- Biology, MedicineJournal of immunology
- 15 September 1987
Immunoglobulin G (IgG) antibodies in polysaccharide-immunized volunteers displayed the subclass pattern previously found in antibodies to meningococcal type A poly Saccharide, which was strikingly different from the composition of the anti-diphtheria toxoid response induced by the same conjugate vaccine.
The percentages of six immunoglobulin isotypes in human antibodies to tetanus toxoid: Standardization of isotype‐specific second antibodies in solid‐phase assay
- I. Seppälä, N. Routonen, A. Sarnesto, P. Mattila, O. Mäkelä
- Biology, MedicineEuropean journal of immunology
It was possible to determine the isotype composition of an antibody population in percent terms for the first time and this was accomplished by standardization of monoclonal antibodies with monoisotypic antibodies rather than myelomas.
Human Antibody Responses to Two Conjugate Vaccines of Haemophilus influenzae Type B Saccharides and Diphtheria Toxin
- I. Seppälä, H. Sarvas, O. Mäkelä, P. Mattila, J. Eskola, H. Käyhty
- BiologyScandinavian journal of immunology
- 1 October 1988
Antigenicity of two Haemophilus influenzae type b (Hib) conjugate vaccines was studied by immunizing adults and 2‐year‐old children, and a large interindividual variation was observed in concentrations of IgG2 of Hib specificity.
The effect of antigen dosage on the response of adoptively transferred cells.
The conclusion is drawn that high concentrations of antigen can paralyse the immunological reaction of primed cells, and both antibody production and IUdR uptake are inhibited.
Autoradiographic studies on the immune response.I. The kinetics of plasma cell proliferation.
The hypothesis was proposed that immunological memory depended on the persistence, following primary stimulation, of a continuously dividing stem line of primitive lymphocytes, reactive at all times to further antigenic stimulation.