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Imipramine

Known as: 3-(5H-DIBENZO[b,F]azepin-5-yl)-N,N-dimethylpropan-1-amine, 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, 10,11-dihydro-N,N-Dimethyl-5H-dibenz[b,F]azepine-5-propanamine 
A synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces… Expand
National Institutes of Health

Related topics

Related topics

44 relations

Narrower (13)

10-hydroxyimipramine2-hydroxyimipramine2-iodoimipramine2-nitroimipramine
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Broader (6)

Adrenergic Uptake InhibitorsAminesAminoacridinesAntidepressive Agents
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Affective Disorders, PsychoticAttention deficit hyperactivity disorderCYP1A2 protein, humanCYP2C19 protein, human
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Systematic Review and Meta-Analysis: Dose-Response Relationship of Selective Serotonin Reuptake Inhibitors in Major Depressive Disorder.
OBJECTIVE Previous studies suggested that the treatment response to selective serotonin reuptake inhibitors (SSRIs) in major… Expand
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Highly Cited
2006
Highly Cited
2006
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
To better understand the molecular mechanisms of depression and antidepressant action, we administered chronic social defeat… Expand
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Highly Cited
2003
Highly Cited
2003
Venlafaxine versus imipramine in painful polyneuropathy: A randomized, controlled trial
Background Tricyclic antidepressants (TCA) are often used in the treatment of painful polyneuropathy. Venlafaxine is a serotonin… Expand
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Highly Cited
2000
Highly Cited
2000
Gender differences in treatment response to sertraline versus imipramine in chronic depression.
OBJECTIVE The authors examined gender differences in treatment response to sertraline, a selective serotonin reuptake inhibitor… Expand
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Highly Cited
2000
Highly Cited
2000
Cognitive-behavioral therapy, imipramine, or their combination for panic disorder: A randomized controlled trial.
CONTEXT Panic disorder (PD) may be treated with drugs, psychosocial intervention, or both, but the relative and combined… Expand
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Highly Cited
1996
Highly Cited
1996
Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus.
The present study demonstrates that chronic, but not acute, adminstration of several different classes of antidepressants… Expand
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Highly Cited
1994
Highly Cited
1994
A comparison of cognitive therapy, applied relaxation and imipramine in the treatment of panic disorder.
Recent studies have shown that cognitive therapy is an effective treatment for panic disorder. However, little is known about how… Expand
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Highly Cited
1988
Highly Cited
1988
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus… Expand
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Highly Cited
1987
Highly Cited
1987
The use of a plus-maze to measure anxiety in the mouse
To investigate whether an elevated plus-maze consisting of two open and two closed arms could be used as a model of anxiety in… Expand
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Highly Cited
1978
Highly Cited
1978
"Behavioural despair" in rats and mice: strain differences and the effects of imipramine.
Rats and mice when forced to swim in a restricted space will rapidly cease attempts to escape and become immobile. Previous… Expand
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