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Imipramine

Known as: 3-(5H-DIBENZO[b,F]azepin-5-yl)-N,N-dimethylpropan-1-amine, 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, 10,11-dihydro-N,N-Dimethyl-5H-dibenz[b,F]azepine-5-propanamine 
A synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces… 
National Institutes of Health

Related topics

Related topics

44 relations

Narrower (13)

10-hydroxyimipramine2-hydroxyimipramine2-iodoimipramine2-nitroimipramine

Broader (6)

Adrenergic Uptake InhibitorsAminesAminoacridinesAntidepressive Agents
Affective Disorders, PsychoticAttention deficit hyperactivity disorderCYP1A2 protein, humanCYP2C19 protein, human

Papers overview

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Highly Cited
1986
Highly Cited
1986
Electroconvulsive shock therapy and maximum binding of platelet tritiated imipramine binding in depression.
We studied the tritiated imipramine binding values in platelets from 12 hospitalized untreated patients with endogenous… 
1984
1984
A Double Blind Study of Imipramine versus Zimelidine in Treatment of Obsessive Compulsive Neurosis
Six patients suffering from obsessive compulsive neurosis were randomly allocated into two groups of three patients each and… 
1984
1984
Imipramine binding in subpopulations of normal human blood platelets.
Imipramine binding was studied in platelet membranes isolated with different proportions of heavy (young) and light (old… 
1981
1981
Quantitative determination of the free amino acids and their derivatives in the common edible mushroom, Agaricus bisporus.
Nitrogen in the ethanol extract of the fruiting bodies of the common edible mushroom, Agaricus bisporus, accounted for about 60… 
1981
1981
Metabolism of imipramine by microorganisms.
The microbial metabolism of imipramine was studied using selected fungal organisms. The major microbial metabolites were isolated… 
1980
1980
The effect of multiple imipramine administration on monoaminergic systems of the rat brain.
Wistar rats received imipramine (IMI) in daily single doses of 1 or 10 mg/kg ip for up to 4 weeks. They were killed after 1,2 or… 
1976
1976
Measurement of clomipramine, N-desmethyl-clomipramine, imipramine, and dehydroimipramine in biological fluids by selective ion monitoring, and pharmacokinetics of clomipramine.
To quantitatively determine tricyclic antidepressant agents, we used a combined gas chromatograph/mass spectrometer system, and… 
1975
1975
Effects of perphenazine on imipramine metabolism in man.
In previous studies we have shown that perphenazine inhibits the metabolism of nortriptyline and imipramine. In this study the… 
1971
1971
Clinical and metabolic studies with imipramine in man.
Six out of seven severely depressed patients improved rapidly on very high doses of imipramine. Clinical improvement correlated… 
Highly Cited
1967
Highly Cited
1967
The endogenous depressive pattern. An empirical investigation.
UNCERTAIN diagnostic criteria and the lack of confirmatory evidence (such as known etiologies or specific treatments) contribute…