FAQ

Imipramine

Known as: 3-(5H-DIBENZO[b,F]azepin-5-yl)-N,N-dimethylpropan-1-amine, 5H-Dibenz(b,f)azepine-5-propanamine, 10,11-dihydro-N,N-dimethyl-, 10,11-dihydro-N,N-Dimethyl-5H-dibenz[b,F]azepine-5-propanamine 
A synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces… (More)

Topic mentions per year

Topic mentions per year

1955-2018
010020019552017

Related topics

Related topics

45 relations

Narrower (16)

10-hydroxyimipramine2,8-dinitroimipramine2-hydroxyimipramine2-nitroimipramine
(More)

Broader (6)

Adrenergic Uptake InhibitorsAminacrineAminesAminoacridines
(More)
Affective Disorders, PsychoticAntidepressive AgentsAttention deficit hyperactivity disorderCYP1A2 protein, human
(More)

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Imipramine
Pain
Depressive disorder
Myocardial Infarction
Drug Allergy
agonists

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action
To better understand the molecular mechanisms of depression and antidepressant action, we administered chronic social defeat… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Brain-derived neurotrophic factor and antidepressant drugs have different but coordinated effects on neuronal turnover, proliferation, and survival in the adult dentate gyrus.
Antidepressants increase proliferation of neuronal progenitor cells and expression of brain-derived neurotrophic factor (BDNF) in… (More)
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Cognitive-behavioral therapy, imipramine, or their combination for panic disorder: A randomized controlled trial.
CONTEXT Panic disorder (PD) may be treated with drugs, psychosocial intervention, or both, but the relative and combined… (More)
  • table 1
  • table 2
  • table 3
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Gender differences in treatment response to sertraline versus imipramine in chronic depression.
OBJECTIVE The authors examined gender differences in treatment response to sertraline, a selective serotonin reuptake inhibitor… (More)
  • table 1
  • table 2
  • figure 1
  • table 3
  • table 4
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Nonspecific binding to microsomes: impact on scale-up of in vitro intrinsic clearance to hepatic clearance as assessed through examination of warfarin, imipramine, and propranolol.
  • Rossend Obach
  • Drug metabolism and disposition: the biological…
  • 1997
The nonspecific, noncovalent binding of three drugs, imipramine, warfarin, and propranolol, to pooled human and animal liver… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Chronic antidepressant administration increases the expression of cAMP response element binding protein (CREB) in rat hippocampus.
The present study demonstrates that chronic, but not acute, adminstration of several different classes of antidepressants… (More)
  • figure 2
  • figure I
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1988
Highly Cited
1988
Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
The effect of various drugs on the extracellular concentration of dopamine in two terminal dopaminergic areas, the nucleus… (More)
  • figure 2
  • figure 1
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
1987
Highly Cited
1987
The use of a plus-maze to measure anxiety in the mouse
To investigate whether an elevated plus-maze consisting of two open and two closed arms could be used as a model of anxiety in… (More)
  • table 2
  • table 3
  • table 4
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
1983
Highly Cited
1983
Egg-laying defective mutants of the nematode Caenorhabditis elegans.
We have isolated 145 fertile mutants of C. elegans that are defective in egg laying and have characterized 59 of them genetically… (More)
  • table 1
  • table 2
  • table 4
  • figure 1
  • figure 2
Is this relevant?
Highly Cited
1978
Highly Cited
1978
"Behavioural despair" in rats and mice: strain differences and the effects of imipramine.
Rats and mice when forced to swim in a restricted space will rapidly cease attempts to escape and become immobile. Previous… (More)
Is this relevant?