Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

2-hydroxyimipramine

 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Imipramine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Imipramine and 2-hydroxyimipramine: comparative cardiotoxicity and pharmacokinetics in swine
The hemodynamic, cardiographic, and initial pharmacokinetic characteristics of the de novo administration of the 2… Expand
  • figure 1
  • table 2
  • table 1
  • table 3
  • figure 2
Is this relevant?
2004
2004
The analysis and disposition of imipramine and its active metabolites in man
Single oral and intramuscular (i.m.) doses of imipramine (IMI) were administered to four normal males. Serum and urine… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 5
  • table 1
Is this relevant?
2000
2000
Pharmacokinetic interaction between imipramine and carbamazepine in patients with major depression
Abstract. Rationale: Despite the fact that carbamazepine (CBZ) is frequently added to the existing tricyclic antidepressant (TCA… Expand
  • figure 1
  • table 1
  • table 2
  • figure 2
Is this relevant?
1999
1999
Eight inhibitory monoclonal antibodies define the role of individual P-450s in human liver microsomal diazepam, 7-ethoxycoumarin, and imipramine metabolism.
Eight inhibitory monoclonal antibodies (MAbs) individually specific to human cytochrome P-450 (P-450) 1A1, 1A2, 2A6, 2B6, 2C… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 2
Is this relevant?
1997
1997
Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and…
Cytochrome P450 (CYP) involved in the two major pathways of imipramine (IMI) was reappraised using human liver microsomes… Expand
  • table 1
  • figure 1
  • figure 2
  • table 2
  • figure 4
Is this relevant?
Highly Cited
1993
Highly Cited
1993
Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver.
The metabolism of imipramine by human liver microsomes was examined using a combination of five strategies. Human hepatic… Expand
Is this relevant?
1991
1991
Role of P450IID6, the target of the sparteine-debrisoquin oxidation polymorphism, in the metabolism of imipramine.
The formation of three oxidative metabolites of imipramine, N-desmethylimipramine (desipramine), 2-hydroxyimipramine, and 10… Expand
Is this relevant?
1988
1988
Multiple-dose pharmacokinetics of imipramine and its major active and conjugated metabolites in depressed patients.
Imipramine (IMI) and its active metabolites, desipramine (DMI), 2-hydroxyimipramine (2-OH-IMI), and 2-hydroxydesipramine (2-OH… Expand
Is this relevant?
1983
1983
Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain.
1 Twenty-two compounds classified as antidepressants, metabolites of antidepressants or putative antidepressants were assayed for… Expand
Is this relevant?
1979
1979
Inhibition of biogenic amines uptake by imipramine, desipramine, 2 OH-imipramine and 2 OH-desipramine in rat brain.
Abstract The tricyclic antidepressant imipramine and its metabolites desipramine, 2-hydroxyimipramine and 2-hydroxydesipramine… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE