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The hemodynamic, cardiographic, and initial pharmacokinetic characteristics of the de novo administration of the 2… Expand Abstract. Rationale: Despite the fact that carbamazepine (CBZ) is frequently added to the existing tricyclic antidepressant (TCA… Expand Cytochrome P450 (CYP) involved in the two major pathways of imipramine (IMI) was reappraised using human liver microsomes… Expand We studied the metabolic disposition of imipramine by measuring imipramine and its metabolites in plasma and urine simultaneously… Expand The metabolism of imipramine by human liver microsomes was examined using a combination of five strategies. Human hepatic… Expand The formation of three oxidative metabolites of imipramine, N‐desmethylimipramine (desipramine), 2‐hydroxyimipramine, and 10… Expand 1 Twenty-two compounds classified as antidepressants, metabolites of antidepressants or putative antidepressants were assayed for… Expand Abstract The tricyclic antidepressant imipramine and its metabolites desipramine, 2-hydroxyimipramine and 2-hydroxydesipramine… Expand The actions of ten tricyclic antidepressant drugs were evaluated with respect to inhibition of the adenylate cyclase-cyclic… Expand Publisher Summary This chapter describes the pharmacological characterization of the prototype agent—imipramine (I). The… Expand