2-hydroxyimipramine

Eight inhibitory monoclonal antibodies (MAbs) individually specific to human cytochrome P-450 (P-450) 1A1, 1A2, 2A6, 2B6, 2C… (More)

The relationship between the genetic polymorphism of S-mephenytoin 4'-hydroxylation catalyzed by CYP2C19 and the N-demethylation… (More)

1. The metabolism of imipramine (N-demethylation and 2-hydroxylation) was studied in relation to the activity of S-mephenytoin 4… (More)

The metabolism of imipramine by human liver microsomes was examined using a combination of five strategies. Human hepatic… (More)

The hemodynamic, cardiographic, and initial pharmacokinetic characteristics of the de novo administration of the 2… (More)

The formation of three oxidative metabolites of imipramine, N-desmethylimipramine (desipramine), 2-hydroxyimipramine, and 10… (More)

Fifteen subjects (seven recently abstinent, male, chronic alcoholics and eight, age- and weight-matched male controls) were… (More)

Imipramine (IMI) and its active metabolites, desipramine (DMI), 2-hydroxyimipramine (2-OH-IMI), and 2-hydroxydesipramine (2-OH… (More)

A fatality following ingestion of the tricyclic antidepressant imipramine (Novopramine), acetaminophen, and ethyl alcohol is… (More)

1 Twenty-two compounds classified as antidepressants, metabolites of antidepressants or putative antidepressants were assayed for… (More)