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2-hydroxyimipramine

National Institutes of Health

Related topics

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2 relations

Broader (1)

Imipramine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Imipramine and 2-hydroxyimipramine: comparative cardiotoxicity and pharmacokinetics in swine
The hemodynamic, cardiographic, and initial pharmacokinetic characteristics of the de novo administration of the 2… Expand
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2000
2000
Pharmacokinetic interaction between imipramine and carbamazepine in patients with major depression
Abstract. Rationale: Despite the fact that carbamazepine (CBZ) is frequently added to the existing tricyclic antidepressant (TCA… Expand
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Highly Cited
1997
Highly Cited
1997
Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: a study using microsomes obtained from putative extensive and poor metabolizers of S-mephenytoin and…
Cytochrome P450 (CYP) involved in the two major pathways of imipramine (IMI) was reappraised using human liver microsomes… Expand
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1994
1994
Metabolic disposition of imipramine in oriental subjects: relation to metoprolol alpha-hydroxylation and S-mephenytoin 4'-hydroxylation phenotypes.
We studied the metabolic disposition of imipramine by measuring imipramine and its metabolites in plasma and urine simultaneously… Expand
Highly Cited
1993
Highly Cited
1993
Major pathway of imipramine metabolism is catalyzed by cytochromes P-450 1A2 and P-450 3A4 in human liver.
The metabolism of imipramine by human liver microsomes was examined using a combination of five strategies. Human hepatic… Expand
Highly Cited
1991
Highly Cited
1991
Role of P450IID6, the target of the sparteine‐debrisoquin oxidation polymorphism, in the metabolism of imipramine
The formation of three oxidative metabolites of imipramine, N‐desmethylimipramine (desipramine), 2‐hydroxyimipramine, and 10… Expand
Highly Cited
1983
Highly Cited
1983
Antagonism by antidepressants of muscarinic acetylcholine receptors of human brain.
1 Twenty-two compounds classified as antidepressants, metabolites of antidepressants or putative antidepressants were assayed for… Expand
Highly Cited
1979
Highly Cited
1979
Inhibition of biogenic amines uptake by imipramine, desipramine, 2 OH-imipramine and 2 OH-desipramine in rat brain.
Abstract The tricyclic antidepressant imipramine and its metabolites desipramine, 2-hydroxyimipramine and 2-hydroxydesipramine… Expand
1976
1976
Influence of tricyclic antidepressants on the adenylate cyclase-phosphodiesterase system in the rat cortex
The actions of ten tricyclic antidepressant drugs were evaluated with respect to inhibition of the adenylate cyclase-cyclic… Expand
Review
1966
Review
1966
The pharmacology of imipramine and related antidepressants.
  • L. Gyermek
  • International review of neurobiology
  • 1966
    • Corpus ID: 2156709
Publisher Summary This chapter describes the pharmacological characterization of the prototype agent—imipramine (I). The… Expand
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