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Genome-wide Expression Profiling of the Response to Polyene, Pyrimidine, Azole, and Echinocandin Antifungal Agents in Saccharomyces cerevisiae*
Genes with the greatest specificity for a particular drug were grouped together as drug-specific genes, whereas genes with a lack of drug specificity were also identified and shed new light on the mechanisms of action of these classes of antifungal agents.
A new dammarane-type triterpene glycoside from Polyscias fulva.
A new dammarane-type triterpene glycoside, polysciasoside A (1), and three known compounds have been isolated from the leaves of Polyscias fulva. The structure of the new compound was established as
Natural Products as a Resource for New Drugs
  • A. Clark
  • Chemistry, Biology
    Pharmaceutical Research
  • 1 August 1996
Natural products have served as a major source of drugs for centuries, and about half of the pharmaceuticals in use today are derived from natural products. The aim of this review is to provide an
Natural products inhibiting Candida albicans secreted aspartic proteases from Lycopodium cernuum.
Activity-guided fractionation of an ethanol extract of Lycopodium cernuum for Candida albicans secreted aspartic proteases (SAP) inhibition resulted in the identification of six new (1-6) and four
Antimicrobial activity of phenolic constituents of Magnolia grandiflora L.
Three phenolic constituents of Magnolia grandiflora L. were shown to possess significant antimicrobial activity using an agar well diffusion assay and the minimum inhibitory concentrations were determined.
Antimicrobial properties of Honduran medicinal plants.
Antimicrobial activity of juglone
The juice of freshly macerated unripe hulls of the black walnut (Juglans nigra) has been used for many years in folk medicine as a treatment for localized, topical fungal infections such as ringworm.
Bioactive 12-oleanene triterpene and secotriterpene acids from Maytenus undata.
The new 3,4-secotriterpene acid 20-epi-koetjapic acid (5) potently inhibited rat neonatal brain microglia phorbol ester-stimulated thromboxane B(2) and superoxide anion (IC(50) = 1.9 microM) generation.
Synthesis and antimicrobial activities of certain cannabichromene and cannabigerol related compounds.
Cannabichromene homologs, analogs, and isomers as well as the C1-homolog and isomer of cannabigerol were prepared and tested for their antimicrobial and antifungal properties. Spectral data of all
Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha.
Compounds 1, 4, and 5 demonstrated in vitro antimalarial activity against Plasmodium falciparum (W-2 clone), while 2 was inactive and 2 showed in vitro cytotoxicity to selected human cancer cell lines (IC50 = 3-6 microg/mL against SK-MEL, KB, BT-549, and SK-OV-3), and 4 was also cytotoxic to human malignant melanoma.