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Antidepressant-like Effect of Tetrahydroisoquinoline Amines in the Animal Model of Depressive Disorder Induced by Repeated Administration of a Low Dose of Reserpine: Behavioral and Neurochemical
It is suggested that both TIQ and 1MeTIQ may be effective for the therapy of depression in clinic as new antidepressants which, when administered peripherally easily penetrate the blood–brain barrier, and as endogenous compounds may not have adverse side effects. Expand
Effects of various Ca2+ channel antagonists on morphine analgesia, tolerance and dependence, and on blood pressure in the rat.
All three Ca2+ antagonists enhanced the analgesia, and prevented development of the naloxone-precipitated withdrawal syndrome, although they differed in their efficacy. Expand
Cortical dihydropyridine binding sites and a behavioral syndrome in morphine-abstinent rats.
The results indicate that the symptoms of abstinence are related to a functional state of cortical dihydropyridine-sensitive calcium channels in morphine-dependent, naloxone-treated rats. Expand
Chronic impairment of the vagus nerve function leads to inhibition of dopamine but not serotonin neurons in rat brain structures.
A close relationship between the peripheral vagus nerve impairment and the inhibition of dopamine system in the brain structures is suggested, the first report of such relationship which may suggest that mental changes could occur in the first stage of Parkinson's disease far ahead of motor impairment. Expand
Reduction of morphine dependence and potentiation of analgesia by chronic co-administration of nifedipine
The present results suggest that opiate tolerance and physical dependence may be separated by coadministration of nifedipine and suggest that the combined chronic treatment with morphine and nifEDipine may increase the efficacy of morphine during chronic treatment and prevent development of abstinence. Expand
1-Methyl-1,2,3,4-tetrahydroisoquinoline Antagonizes a Rise in Brain Dopamine Metabolism, Glutamate Release in Frontal Cortex and Locomotor Hyperactivity Produced by MK-801 but not the Disruptions of
1MeTIQ, an endogenous neuroprotective compound, exhibits also antipsychotic-like efficacy in some animal tests, and may be useful in clinical practice as a psychosis-attenuating drug in schizophrenic patients. Expand
1-Methyl-1,2,3,4-Tetrahydroisoquinoline, an Endogenous Amine with Unexpected Mechanism of Action: New Vistas of Therapeutic Application
The results strongly support the view that 1MeTIQ has a considerable potential as a drug for combating substance abuse, through the attenuation of craving, and believe that MAO inhibition, free radicals scavenging properties, and antagonism to the glutamatergic system may play an essential role in neuroprotection. Expand
Chronic Salsolinol Administration Prevents the Behavioral and Neurochemical Effects of l-DOPA in Rats
It is proposed that an elevated salsolinol level in parkinsonian patients may represent a serious risk factor of the clinical efficacy of l-DOPA therapy. Expand
Dopamine receptors in the striatum and limbic system of various strains of mice: Relation to differences in responses to apomorphine
Dopamine receptors, defined as [3H]spiroperidol binding sites, had similar population parameters in the limbic forebrain of C57BL/6, Albino Swiss and DBA/2 mice, but the parameters of the striatalExpand
Protective effect of 1-methyl-1,2,3,4-tetrahydroisoquinoline against dopaminergic neurodegeneration in the extrapyramidal structures produced by intracerebral injection of rotenone.
The data suggest that rotenone given peripherally affects metabolic processes in dopaminergic neurons, and this seems to result from its neurotoxic action, which may be observed after an intracerebral injection. Expand