IRS1 gene

Known as: IRS1, Insulin Receptor Substrate 1 Gene, HIRS-1 
This gene plays a role in signal transduction and carbohydrate metabolism. It is involved in mediation of the insulin response.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Hypoxic microenvironment supports cancer stem cell survival, causes poor response to anticancer therapy and tumor recurrence… (More)
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Highly Cited
2009
Highly Cited
2009
Genome-wide association studies have identified common variants that only partially explain the genetic risk for type 2 diabetes… (More)
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Highly Cited
2008
Highly Cited
2008
Recent evidence suggests that alterations in insulin/insulin-like growth factor 1 (IGF1) signaling (IIS) can increase mammalian… (More)
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Highly Cited
2004
Highly Cited
2004
Elucidating the signalling mechanisms by which obesity leads to impaired insulin action is critical in the development of… (More)
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Highly Cited
2001
Highly Cited
2001
A pathway sensitive to rapamycin, a selective inhibitor of mammalian target of rapamycin (mTOR), down-regulates effects of… (More)
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Highly Cited
1998
Highly Cited
1998
The sphingomyelin derivative ceramide is a signaling molecule implicated in numerous physiological events. Recently published… (More)
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Highly Cited
1998
Highly Cited
1998
Insulin and insulin receptor substrate 1 (IRS-1) are capable of protecting liver cells from apoptosis induced by transforming… (More)
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Highly Cited
1996
Highly Cited
1996
Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obesity and diabetes through its… (More)
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Highly Cited
1995
Highly Cited
1995
Paxillin, a focal-adhesion-associated protein, becomes phosphorylated in response to a number of stimuli which also induce the… (More)
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Highly Cited
1994
Highly Cited
1994
Insulin stimulation drives the formation of a complex between tyrosine-phosphorylated insulin receptor substrate 1 (IRS-1) and 1… (More)
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