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IRS1 gene

Known as: IRS1, Insulin Receptor Substrate 1 Gene, HIRS-1 
This gene plays a role in signal transduction and carbohydrate metabolism. It is involved in mediation of the insulin response.
National Institutes of Health

Related topics

Related topics

5 relations
Diabetes MellitusSignal Transductioninsulin receptor substrate 1 proteinprotein protein interaction

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IRS1 wt Allele

Papers overview

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Highly Cited
2011
Highly Cited
2011
Fucoxanthin exerts differing effects on 3T3-L1 cells according to differentiation stage and inhibits glucose uptake in mature adipocytes.
Highly Cited
2008
Highly Cited
2008
Protein kinase A suppresses the differentiation of 3T3-L1 preadipocytes
cAMP and protein kinase A (PKA) are widely known as signaling molecules that are important for the induction of adipogenesis… 
Highly Cited
2006
Highly Cited
2006
T‐antigen of the human polyomavirus JC attenuates faithful DNA repair by forcing nuclear interaction between IRS‐1 and Rad51
JC polyomavirus (JCV), which infects 90% of the human population, is detectable in human tumors. Its early protein, JCV T‐antigen… 
Highly Cited
1997
Highly Cited
1997
Molecular analysis of insulin resistance in isolated ventricular cardiomyocytes of obese Zucker rats.
Isolated ventricular cardiomyocytes obtained from lean and genetically (fa/fa) obese Zucker rats were used to correlate… 
Highly Cited
1995
Highly Cited
1995
The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.
Recent experimental evidence has focused attention to the role of two molecules, insulin receptor substrate 1 (IRS-1) and… 
Highly Cited
1995
Highly Cited
1995
Insulin Regulation of Membrane-associated Insulin Receptor Substrate 1 (*)
Insulin stimulation of 3T3-L1 adipocytes results in rapid activation of the insulin receptor tyrosine kinase followed by… 
Highly Cited
1994
Highly Cited
1994
Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras
Shc proteins are phosphorylated on tyrosine residues and associate with growth factor receptor-bound protein 2 (Grb2) upon… 
Highly Cited
1994
Highly Cited
1994
Insulin receptor substrate 1 mediates the stimulatory effect of insulin on GLUT4 translocation in transfected rat adipose cells.
Highly Cited
1994
Highly Cited
1994
Insulin signalling: the role of insulin receptor substrate 1.
Highly Cited
1993
Highly Cited
1993
Insulin receptor substrate 1 mediates insulin and insulin-like growth factor I-stimulated maturation of Xenopus oocytes.
Insulin and insulin-like growth factor I (IGF-I) initiate cellular functions by activating their homologous tyrosine kinase… 
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