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Insulin signalling and the regulation of glucose and lipid metabolism
The epidemic of type 2 diabetes and impaired glucose tolerance is one of the main causes of morbidity and mortality worldwide. In both disorders, tissues such as muscle, fat and liver become less…
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Critical nodes in signalling pathways: insights into insulin action
TLDR
The concept of 'critical nodes' is used to define the important junctions in these pathways and illustrate their unique role using insulin signalling as a model system.
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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
TLDR
The results implicate PGC-1 as a key modulator of hepatic gluconeogenesis and as a central target of the insulin–cAMP axis in liver.
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Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
TLDR
It is demonstrated that insulin resistance and DM associate with reduced expression of multiple nuclear respiratory factor-1 (NRF-1)-dependent genes encoding key enzymes in oxidative metabolism and mitochondrial function.
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Developmental Origin of Fat: Tracking Obesity to Its Source
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Suppression of Aging in Mice by the Hormone Klotho
TLDR
It is shown that overexpression of Klotho in mice extends life span and it is suggested that Klotha-mediated inhibition of insulin and IGF1 signaling contributes to its anti-aging properties.
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Type 2 diabetes mellitus
TLDR
The greatest need is for agents that enhance insulin sensitivity, halt the progressive pancreatic β-cell failure that is characteristic of T2DM and prevent or reverse the microvascular complications.
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SIRT 3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation
TLDR
It is reported that SIRT3 expression is upregulated during fasting in liver and brown adipose tissues, and acetylation is identified as a novel regulatory mechanism for mitochondrial fatty-acid oxidation and Sirt3 modulates mitochondrial intermediary metabolism and fatty- acid use during fasting.
Antioxidants prevent health-promoting effects of physical exercise in humans
TLDR
Consistent with the concept of mitohormesis, exercise-induced oxidative stress ameliorates insulin resistance and causes an adaptive response promoting endogenous antioxidant defense capacity and supplementation with antioxidants may preclude these health-promoting effects of exercise in humans.
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The insulin signaling system.
  • M. White, C. Kahn
  • Medicine, Biology
    The Journal of biological chemistry
  • 7 January 1994
View on PubMed
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