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- Publications
- Influence
Critical nodes in signalling pathways: insights into insulin action
- C. M. Taniguchi, B. Emanuelli, C. Kahn
- Biology, Medicine
- Nature Reviews Molecular Cell Biology
- 1 February 2006
Physiologically important cell-signalling networks are complex, and contain several points of regulation, signal divergence and crosstalk with other signalling cascades. Here, we use the concept of… Expand
Insulin resistance differentially affects the PI 3-kinase- and MAP kinase-mediated signaling in human muscle.
- K. Cusi, K. Maezono, +6 authors L. Mandarino
- Biology, Medicine
- The Journal of clinical investigation
- 1 February 2000
The broad nature of insulin resistant glucose metabolism in skeletal muscle of patients with type 2 diabetes suggests a defect in the proximal part of the insulin signaling network. We sought to… Expand
Suppressor of Cytokine Signaling 1 (SOCS-1) and SOCS-3 Cause Insulin Resistance through Inhibition of Tyrosine Phosphorylation of Insulin Receptor Substrate Proteins by Discrete Mechanisms
ABSTRACT Insulin resistance is a pathophysiological component of type 2 diabetes and obesity and also occurs in states of stress, infection, and inflammation associated with an upregulation of… Expand
Insulin receptor signaling in normal and insulin-resistant states.
- J. Boucher, André Kleinridders, C. Kahn
- Biology, Medicine
- Cold Spring Harbor perspectives in biology
- 2014
In the wake of the worldwide increase in type-2 diabetes, a major focus of research is understanding the signaling pathways impacting this disease. Insulin signaling regulates glucose, lipid, and… Expand
Insulin action and the insulin signaling network.
- B. Cheatham, C. Kahn
- Biology, Medicine
- Endocrine reviews
- 1 April 1995
I. Introduction IN THE fasted state, glucose homeostasis depends upon the balance between hepatic glucose production and glucose utilization by the major insulin-dependent tissues, such as liver,… Expand
Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance.
- A. Virkamäki, K. Ueki, C. Kahn
- Biology, Medicine
- The Journal of clinical investigation
- 1 April 1999
Insulin is an anabolic hormone with powerful metabolic effects. The events after insulin binds to its receptor are highly regulated and specific. Defining the key steps that lead to the specificity… Expand
Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation.
- B. Cheatham, C. Vlahos, L. Cheatham, L. Wang, J. Blenis, C. Kahn
- Biology, Medicine
- Molecular and cellular biology
- 1 July 1994
Phosphatidylinositol 3-kinase (PI 3-kinase) is stimulated by insulin and a variety of growth factors, but its exact role in signal transduction remains unclear. We have used a novel, highly specific… Expand
Bidirectional modulation of insulin action by amino acids.
- M. Patti, E. Brambilla, L. Luzi, E. Landaker, C. Kahn
- Biology, Medicine
- The Journal of clinical investigation
- 1 April 1998
Amino acids have been shown to stimulate protein synthesis, inhibit proteolysis, and decrease whole-body and forearm glucose disposal. Using cultured hepatoma and myotube cells, we demonstrate that… Expand
Cellular bioenergetics as a target for obesity therapy
Obesity develops when energy intake exceeds energy expenditure. Although most current obesity therapies are focused on reducing calorific intake, recent data suggest that increasing cellular energy… Expand