IRL 1620

Known as: IRL-1620, l-tryptophan, n-(3-carboxy-1-oxopropyl)-l-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-alanyl-L-histidyl-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-isoleucyl-fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone, hemihydrate 
 
National Institutes of Health

Papers overview

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2015
2015
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by severe cognitive impairment that ultimately… (More)
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2014
2014
Alzheimer's disease (AD) is a progressive brain disorder leading to impairment of learning and memory. Amyloid β (Aβ) induced… (More)
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2013
2013
Endothelin B receptor agonist, IRL-1620, has been shown in previous studies, conducted in our lab, to provide significant… (More)
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2012
2012
We have earlier shown that stimulation of endothelin B receptors by IRL-1620 provides significant neuroprotection at 24h… (More)
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2011
2011
Endothelin and its receptors have long been considered therapeutic targets in the treatment of ischemic stroke. Recent studies… (More)
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2009
2009
IRL-1620, a highly selective ET(B) receptor agonist, is presently in a phase I clinical trial (NCT00613691) in the United States… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Numerous men develop postprostatectomy erectile dysfunction (PPED), due to surgery-related nervous damage. PPED is… (More)
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2004
2004
Nitric oxide (NO) has been shown to be a physiological antagonist of the potent pressor agent endothelin-1, a transcriptional and… (More)
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1996
1996
The present study evaluated the effects and mechanisms of action of endothelin-1 (ET-1) on medullary and cortical blood flow (MBF… (More)
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Highly Cited
1994
Highly Cited
1994
There is accumulating evidence that endothelial cells express a non-isopeptide-selective endothelin (ET) receptor, ETB, which may… (More)
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