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IRL 1620

Known as: IRL-1620, l-tryptophan, n-(3-carboxy-1-oxopropyl)-l-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-alanyl-L-valyl-L-tyrosyl-L-phenylalanyl-L-alanyl-L-histidyl-L-leucyl-L-alpha-aspartyl-L-isoleucyl-L-isoleucyl-fluoro-11beta,16alpha,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone, hemihydrate 
 
National Institutes of Health

Papers overview

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2015
2015
Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by severe cognitive impairment that ultimately… Expand
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2014
2014
Alzheimer's disease (AD) is a progressive brain disorder leading to impairment of learning and memory. Amyloid β (Aβ) induced… Expand
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2012
2012
We have earlier shown that stimulation of endothelin B receptors by IRL-1620 provides significant neuroprotection at 24h… Expand
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Highly Cited
2003
Highly Cited
2003
Endothelins are thought to act through two specific, plasmalemmal G protein-coupled receptor subtypes, ETAR and ETBR. However, in… Expand
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Highly Cited
2001
Highly Cited
2001
We previously demonstrated a differential activation of the endothelin-1 (ET-1) pathway in male and female deoxycorticosterone… Expand
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2000
2000
Aim: To examine the mechanisms underlying the elevated plasma endothelin‐1 (ET‐1) in diabetes and its vascular effects. 
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Highly Cited
1997
Highly Cited
1997
Endothelin (ET) synthesis is enhanced at sites of ischemia or in injured vessels. The purpose of this study was to explore the… Expand
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Highly Cited
1996
Highly Cited
1996
The present study evaluated the effects and mechanisms of action of endothelin-1 (ET-1) on medullary and cortical blood flow (MBF… Expand
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Highly Cited
1995
Highly Cited
1995
The aim of this study was to investigate the potential role of endothelin (ET) in the development of chronic hypoxic pulmonary… Expand
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Highly Cited
1994
Highly Cited
1994
There is accumulating evidence that endothelial cells express a non-isopeptide-selective endothelin (ET) receptor, ETB, which may… Expand
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