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Collectively, the endothelins and their receptors — referred to as the endothelin (ET) axis — have key physiological functions in… Expand During the past 20 years, it has become generally accepted that the modulation of fibroblastic cells towards the myofibroblastic… Expand BACKGROUND
Endothelin 1, a powerful endogenous vasoconstrictor and mitogen, might be a cause of pulmonary hypertension. We… Expand Prostate cancer is the second most common cause of death from cancer in U.S. men, and advanced, hormone–refractory disease is… Expand Exogenous endothelin (ET) is rapidly cleared from the circulation. We investigated which ET receptor subtypes (ETA and ETB… Expand BackgroundEndothelin is a family of potent vasoconstrictor peptides of vascular endothelial origin. Although it has been proposed… Expand Background Endothelins are recently characterized vasoconstrictor peptides. As chronic heart failure (CHF) is characterized by… Expand This study was designed to examine whether endothelin is released from the intima of intact arteries, and whether endothelium… Expand An endothelium-derived 21-residue vasoconstrictor peptide, endothelin, has been isolated, and shown to be one of the most potent… Expand