• Publications
  • Influence
NO as a signalling molecule in the nervous system
  • J. Esplugues
  • Biology, Medicine
  • British journal of pharmacology
  • 1 March 2002
There is growing evidence that nNOS biosynthesis in excitable tissues is not restricted to neurones while substantial amounts of this enzyme have been identified in skeletal muscle, where it is involved in the regulation of metabolism and muscle contractility. Expand
Inhibition of mitochondrial function by efavirenz increases lipid content in hepatic cells
Clinical concentrations of EFV induce bioenergetic stress in hepatic cells by acutely inhibiting mitochondrial function and a new mechanism of mitochondrial interference leads to an accumulation of lipids in the cytoplasm that is mediated by activation of AMPK. Expand
Mitochondrial interference by anti-HIV drugs: mechanisms beyond Pol-γ inhibition.
This review aims to provide a comprehensive overview of the mechanisms and factors which influence the mitochondrial involvement in the toxicity of all three major classes of anti-HIV drugs. Expand
Efavirenz and the CNS: what we already know and questions that need to be answered.
This review offers a comprehensive overview of the current evidence on the interaction that efavirenz displays with the CNS, including the penetration and concentration of the drug in the brain, and discusses the prevalence, types and specificities of its side effects. Expand
Inhibition of mitochondrial respiration by endogenous nitric oxide: A critical step in Fas signaling
It is found that activation of human adult T cell leukemia (Jurkat) cells with anti-Fas Ab leads, in a concentration-dependent manner, to an early burst of production of nitric oxide (NO), which inhibits cell respiration, suggesting that the early NO-dependent phase represents a protective mechanism. Expand
Role of free radicals in sepsis: antioxidant therapy.
The protective role of antioxidants against homeostatic disturbances such as those caused by endotoxin toxicity, their potential clinical use and the effects on the redox state of the immune cells is discussed. Expand
Nitric oxide: Relation to integrity, injury, and healing of the gastric mucosa
iNOS activity may be associated to reduced leukocyte‐endothelium interaction and platelet aggregation as well as protection of mucosal microcirculation and may be important to resolve inflammation by increasing apoptosis in inflammatory cells. Expand
Compromising mitochondrial function with the antiretroviral drug efavirenz induces cell survival‐promoting autophagy
Clinical concentrations of EFV induce autophagy and, in particular, mitophagy in hepatic cells, which suggests that autophagic acts as an adaptive mechanism of cell survival, but exceeding a certain threshold of mitochondrial dysfunction is associated with an Autophagic overload or stress. Expand
Succinate receptor mediates intestinal inflammation and fibrosis
It is shown that both serum and intestinal succinate levels and SUCNR1 expression in intestinal surgical resections were higher in Crohn's disease patients than in controls and a role for S UCNR1 in murine intestinal inflammation and fibrosis is shown. Expand
Lack of mitochondrial toxicity of darunavir, raltegravir and rilpivirine in neurons and hepatocytes: a comparison with efavirenz.
Darunavir, rilpivirine and raltegravir do not induce toxic effects on Hep3B cells and primary rat neurons, which suggests a safer hepatic and neurological profile than that of efavirenz. Expand