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Endothelin Receptor

Known as: Receptors, Endothelin, Receptor, Endothelin, Receptors, Endothelin [Chemical/Ingredient] 
Cell surface proteins that bind ENDOTHELINS with high affinity and trigger intracellular changes which influence the behavior of cells.
National Institutes of Health

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Related topics

9 relations

Narrower (3)

Dear1 protein, mousePD 147953Pael-R protein, Drosophila
EDNRA geneEndothelinIn Bloodagonists

Papers overview

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Highly Cited
2011
Highly Cited
2011
Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma.
Glaucoma is one of the most common neurodegenerative diseases. Despite this, the earliest stages of this complex disease are… 
Highly Cited
2011
Highly Cited
2011
Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial…
Review
2004
Review
2004
Clinical Pharmacology of Bosentan, a Dual Endothelin Receptor Antagonist
Bosentan, a dual endothelin receptor antagonist, is indicated for the treatment of patients with pulmonary arterial hypertension… 
Highly Cited
2001
Highly Cited
2001
The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions
During clinical trials bosentan, the first orally active endothelin receptor antagonist, caused asymptomatic transaminase… 
Highly Cited
1995
Highly Cited
1995
Evidence for endothelin-1-mediated vasoconstriction in severe chronic heart failure
Highly Cited
1994
Highly Cited
1994
Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels.
BACKGROUND Endothelin (ET)-1 has potent vascular effects. Two endothelin receptors have been cloned, namely, the ETA receptor… 
Review
1994
Review
1994
Free radicals in diabetic endothelial cell dysfunction.
Highly Cited
1993
Highly Cited
1993
Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells.
Endothelins (ET) produce endothelium-dependent vasodilation through nitric oxide (NO) synthesis. The present study was designed… 
Highly Cited
1991
Highly Cited
1991
Elevated glucose impairs endothelium-dependent relaxation by activating protein kinase C.
A possible relationship between protein kinase C activation and impaired receptor-mediated endothelium-dependent relaxation in… 
Highly Cited
1991
Highly Cited
1991
Cloning and functional expression of a vascular smooth muscle endothelin 1 receptor.
By screening a cDNA library derived from the A10 rat vascular smooth muscle cell line for functional expression in COS cells, we… 
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