• Publications
  • Influence
Pharmacokinetics of the novel antipsychotic agent risperidone and the prolactin response in healthy subjects
It is concluded that risperidone metabolic polymorphism on increased plasma prolactin is minimal and that the active moiety is clinically relevant. Expand
Pharmacokinetics and pharmacodynamics of the endothelin‐receptor antagonist bosentan in healthy human subjects
Bosentan (Ro 47‐0203) is a potent and mixed ETA‐ and ETB‐receptor antagonist. Its activity has been studied in a variety of preclinical disease models.
Multiple‐Dose Pharmacokinetics, Safety, and Tolerability of Bosentan, an Endothelin Receptor Antagonist, in Healthy Male Volunteers
The multiple‐dose pharmacokinetics, safety, and tolerability of oral bosentan, a selective endothelin receptor antagonist, were investigated in healthy male volunteers and the drug was very well tolerated. Expand
Absorption, Metabolism, and Excretion of Intravenously and Orally Administered [14C]Telmisartan in Healthy Volunteers
No changes in vital signs, electrocardiogram, or clinical laboratory tests were detected following telmisartan administration, and adverse events, predominantly unrelated to treatment and of mild intensity, were infrequent. Expand
Single‐dose subcutaneous administration of recombinant human parathyroid hormone [rhPTH(1–84)] in healthy postmenopausal volunteers
Parathyroid hormone [PTH(1–84)], intended for treatment of osteoporosis because it stimulates new bone formation of normal structure and composition, has become available for therapeutic evaluation. Expand
The Effect of Telmisartan on the Steady‐State Pharmacokinetics of Digoxin in Healthy Male Volunteers
Although there was some evidence for a pharmacokinetic interaction between digoxin and telmisartan found in this study, the safety and tolerability of digoxin were unaffected by concurrent administration of tel Misartan in the study population. Expand
Inhibitory Effect of Telmisartan on the Blood Pressure Response to Angiotensin II Challenge
Telmisartan is a new angiotensin receptor antagonist possessing potent, selective, and insurmountable inhibitory activity specific to the angiotensin II type 1 (AT 1 ) receptor. The current study wasExpand
The absolute bioavailability and effect of food on the pharmacokinetics of zolmitriptan in healthy volunteers.
At therapeutic doses zolmitriptan has good oral bioavailability in healthy volunteers and has dose-proportional pharmacokinetics that are not affected by food to any clinically relevant extent. Expand
Pharmacokinetic drug interaction studies with candesartan cilexetil.
Canesartan cilexetil was well tolerated both alone and in combination with the other agents and no other co-administered drug affected the pharmacokinetic parameters of candesartan. Expand
Absorption and mass balance of piperonyl butoxide following an 8-h dermal exposure in human volunteers.
The absorption of PBO either by itself or formulated was very poor, as demonstrated by the radioactivity excreted in the urine, and radioactivity in the ipsilateral plasma, as well as the HPLC retention times for these metabolites are different than that seen in rats. Expand