• Publications
  • Influence
Cardiac excitation–contraction coupling
  • D. Bers
  • Physics, Medicine
  • Nature
  • 10 January 2002
TLDR
Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the most important and spatial microdomains within the cell are important in localizing the molecular players that orchestrate cardiac function. Expand
Excitation-Contraction Coupling and Cardiac Contractile Force
  • D. Bers
  • Developments in Cardiovascular Medicine
  • 2001
Read more and get great! That's what the book enPDFd excitation contraction coupling and cardiac contractile force will give for every reader to read this book. This is an on-line book provided inExpand
Calcium cycling and signaling in cardiac myocytes.
  • D. Bers
  • Biology, Medicine
  • Annual review of physiology
  • 13 February 2008
TLDR
This review focuses on Ca signaling in cardiac myocytes as pertaining to electrophysiology, excitation-contraction coupling, modulation of contractile function, energy supply-demand balance, cell death, and transcription regulation. Expand
A practical guide to the preparation of Ca2+ buffers.
TLDR
Practical tools are provided to help in the making and calibration of Ca2+-buffered solutions for a wide array of biological applications and some basic principles ofCa2+ buffering are discussed. Expand
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.
TLDR
A detailed mathematical model for Ca2+ handling and ionic currents in the rabbit ventricular myocyte is developed, more robust than many previously existing models and reproduces many experimental results using parameters based largely on experimental measurements in myocytes. Expand
Relaxation in rabbit and rat cardiac cells: species‐dependent differences in cellular mechanisms.
TLDR
During the decline of the [Ca2+]i transient, the Na(+)‐ Ca2+ exchange is about 2‐ to 3‐fold faster in rabbit than in rat, whereas the SR Ca(2+)‐ATPase is 2‐to 3‐ fold faster in the rat. Expand
Calcium fluxes involved in control of cardiac myocyte contraction.
  • D. Bers
  • Biology, Medicine
  • Circulation research
  • 18 August 2000
This Review is part of a thematic series on Calcium Cycling in Cardiovascular Cells , which includes the following articles: Ca2+ Release Mechanisms, Ca2+ Sparks, and Local Control ofExpand
Arrhythmogenesis and Contractile Dysfunction in Heart Failure: Roles of Sodium-Calcium Exchange, Inward Rectifier Potassium Current, and Residual &bgr;-Adrenergic Responsiveness
TLDR
Data is presented to support a novel paradigm in which changes in NaCaX and IK1, and residual &bgr;-AR responsiveness, conspire to greatly increase the propensity for triggered arrhythmias in HF. Expand
Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations.
TLDR
A point model of the cardiac myofilament is developed to simulate a wide variety of experimental muscle characterizations including Force-Ca relations and twitches under isometric, isosarcometric, isotonic, and auxotonic conditions and demonstrates that the feedback effects of force on Ca binding to troponin can modify the cytosolic Ca transient. Expand
Ca2+/Calmodulin–Dependent Protein Kinase Modulates Cardiac Ryanodine Receptor Phosphorylation and Sarcoplasmic Reticulum Ca2+ Leak in Heart Failure
TLDR
The results suggest that CaMKII-dependent phosphorylation of RyR2 is involved in enhanced SR diastolic Ca leak and reduced SR Ca load in HF, and may thus contribute to arrhythmias and contractile dysfunction in HF. Expand
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