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Cardiac excitation–contraction coupling
- D. Bers
- Biology, PhysicsNature
- 10 January 2002
Of the ions involved in the intricate workings of the heart, calcium is considered perhaps the most important and spatial microdomains within the cell are important in localizing the molecular players that orchestrate cardiac function.
Excitation-Contraction Coupling and Cardiac Contractile Force
- D. Bers
- Biology, MedicineDevelopments in Cardiovascular Medicine
- 30 April 1991
A large number of the cellular structures involved in E-C coupling, including myofilaments, are involved in cardiac contraction by SR and sarcolemmal Ca fluxes, and Ca inotropy and Ca mismanagement is studied.
Calcium cycling and signaling in cardiac myocytes.
- D. Bers
- BiologyAnnual Review of Physiology
- 13 February 2008
This review focuses on Ca signaling in cardiac myocytes as pertaining to electrophysiology, excitation-contraction coupling, modulation of contractile function, energy supply-demand balance, cell death, and transcription regulation.
A practical guide to the preparation of Ca2+ buffers.
A mathematical treatment of integrated Ca dynamics within the ventricular myocyte.
- T. Shannon, Fei Wang, J. Puglisi, Christopher R. Weber, D. Bers
- BiologyBiophysical Journal
- 1 November 2004
A detailed mathematical model for Ca2+ handling and ionic currents in the rabbit ventricular myocyte is developed, more robust than many previously existing models and reproduces many experimental results using parameters based largely on experimental measurements in myocytes.
Relaxation in rabbit and rat cardiac cells: species‐dependent differences in cellular mechanisms.
During the decline of the [Ca2+]i transient, the Na(+)‐ Ca2+ exchange is about 2‐ to 3‐fold faster in rabbit than in rat, whereas the SR Ca(2+)‐ATPase is 2‐to 3‐ fold faster in the rat.
Fractional SR Ca release is regulated by trigger Ca and SR Ca content in cardiac myocytes.
This study assessed how the fractional SR Ca release as described by Bassani et al. is affected by alteration of trigger Ca and of SR Ca content and found it to be very close to the limiting SR Ca capacity.
Calcium fluxes involved in control of cardiac myocyte contraction.
- D. Bers
- BiologyCirculation Research
- 18 August 2000
This Review is part of a thematic series on Calcium Cycling in Cardiovascular Cells , which includes the following articles: Ca2+ Release Mechanisms, Ca2+ Sparks, and Local Control of…
Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations.
A point model of the cardiac myofilament is developed to simulate a wide variety of experimental muscle characterizations including Force-Ca relations and twitches under isometric, isosarcometric, isotonic, and auxotonic conditions and demonstrates that the feedback effects of force on Ca binding to troponin can modify the cytosolic Ca transient.
Arrhythmogenesis and Contractile Dysfunction in Heart Failure: Roles of Sodium-Calcium Exchange, Inward Rectifier Potassium Current, and Residual &bgr;-Adrenergic Responsiveness
Data is presented to support a novel paradigm in which changes in NaCaX and IK1, and residual &bgr;-AR responsiveness, conspire to greatly increase the propensity for triggered arrhythmias in HF.