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Endothelin-1

Known as: Endothelin-1 [Chemical/Ingredient], ET-1, Endothelin 1 
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the… Expand
National Institutes of Health

Related topics

Related topics

30 relations

Narrower (6)

Alexa532-endothelin 1Preproendothelin-1Proendothelin (1-38)endothelin-1 (1-21)
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Cardiac Hypertrophy PathwayEDN1 geneEndothelin-1 measurementEndothelin-2
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Broader (1)

Endothelin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study
BACKGROUND Endothelin 1, a powerful endogenous vasoconstrictor and mitogen, might be a cause of pulmonary hypertension. We… Expand
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Highly Cited
2000
Highly Cited
2000
Endothelins and Endothelin Receptor Antagonists: Therapeutic Considerations for a Novel Class of Cardiovascular Drugs
The 21-amino acid peptide endothelin-1 (ET-1) is the predominant isoform of the endothelin peptide family, which includes ET-2… Expand
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Highly Cited
1998
Highly Cited
1998
Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells…
Endothelial dysfunction associated with atherosclerosis has been attributed to alterations in the L-arginine-nitric oxide (NO… Expand
Highly Cited
1994
Highly Cited
1994
ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
Endothelin-1 (ET-1), a 21-residue vasoactive peptide, is produced in vascular endothelial cells from the 38-residue inactive… Expand
Highly Cited
1994
Highly Cited
1994
Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1
The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient… Expand
Highly Cited
1994
Highly Cited
1994
Clearance of circulating endothelin-1 by ETB receptors in rats.
Exogenous endothelin (ET) is rapidly cleared from the circulation. We investigated which ET receptor subtypes (ETA and ETB… Expand
Highly Cited
1994
Highly Cited
1994
Contribution of endogenous generation of endothelin-1 to basal vascular tone
Endothelin-1 is an endothelium-derived vasoconstrictor peptide, possibly involved in the pathophysiology of cardiovascular… Expand
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Highly Cited
1993
Highly Cited
1993
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.
BACKGROUND Pulmonary hypertension is characterized by an increase in vascular tone or an abnormal proliferation of muscle cells… Expand
Review
1991
Review
1991
Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?
OBJECTIVE To explore the role of endothelin-1, a potent endothelial-derived vasoconstrictor peptide, in pulmonary hypertension… Expand
Highly Cited
1990
Highly Cited
1990
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
ENDOTHELIN-1 was initially identified as a 21-residue potent vasoconstrictor peptide produced by vascular endothelial cells, but… Expand
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