Endothelin-1

Known as: Endothelin-1 [Chemical/Ingredient], ET-1, Endothelin 1 
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the… (More)
National Institutes of Health

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Alexa532-endothelin 1Preproendothelin-1Proendothelin (1-38)endothelin-1 (1-21)
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Cardiac Hypertrophy PathwayEDN1 geneEndothelin-1 measurementEndothelin-2
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Broader (1)

Endothelin

Papers overview

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Review
2018
Review
2018
Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases.
Reactive oxygen species (ROS) are reactive intermediates of molecular oxygen that act as important second messengers within the… (More)
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Highly Cited
2002
Highly Cited
2002
Endothelin antagonism and interleukin-6 inhibition attenuate the proatherogenic effects of C-reactive protein.
BACKGROUND C-reactive protein (CRP) has been suggested to actively participate in the development of atherosclerosis. In the… (More)
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Highly Cited
1999
Highly Cited
1999
Peroxisome proliferator-activated receptor activators inhibit thrombin-induced endothelin-1 production in human vascular endothelial cells by inhibiting the activator protein-1 signaling pathway.
Endothelin-1 (ET-1), a 21-amino acid vasoactive peptide mainly produced by vascular endothelial cells, is involved in the… (More)
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Highly Cited
1994
Highly Cited
1994
Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1
The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient… (More)
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Highly Cited
1994
Highly Cited
1994
ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
Endothelin-1 (ET-1), a 21-residue vasoactive peptide, is produced in vascular endothelial cells from the 38-residue inactive… (More)
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Highly Cited
1994
Highly Cited
1994
Contribution of endogenous generation of endothelin-1 to basal vascular tone
Endothelin-1 is an endothelium-derived vasoconstrictor peptide, possibly involved in the pathophysiology of cardiovascular… (More)
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Highly Cited
1994
Highly Cited
1994
Clearance of circulating endothelin-1 by ETB receptors in rats.
Exogenous endothelin (ET) is rapidly cleared from the circulation. We investigated which ET receptor subtypes (ETA and ETB… (More)
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Highly Cited
1993
Highly Cited
1993
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.
BACKGROUND Pulmonary hypertension is characterized by an increase in vascular tone or an abnormal proliferation of muscle cells… (More)
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Highly Cited
1992
Highly Cited
1992
Polar secretion of endothelin-1 by cultured endothelial cells.
The aim of this study was to determine the permeability of endothelial monolayers for endothelin-1 and a possible directionality… (More)
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Highly Cited
1992
Highly Cited
1992
Plasma endothelin correlates with the extent of pulmonary hypertension in patients with chronic congestive heart failure.
BACKGROUND Endothelin is a family of potent vasoconstrictor peptides of vascular endothelial origin. Although it has been… (More)
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