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Endothelin-1

Known as: Endothelin-1 [Chemical/Ingredient], ET-1, Endothelin 1 
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the… 
National Institutes of Health

Related topics

Related topics

30 relations

Narrower (6)

Alexa532-endothelin 1Preproendothelin-1Proendothelin (1-38)endothelin-1 (1-21)
Cardiac Hypertrophy PathwayEDN1 geneEndothelin-1 measurementEndothelin-2

Broader (1)

Endothelin

Papers overview

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Highly Cited
2001
Highly Cited
2001
Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study
Highly Cited
2000
Highly Cited
2000
Endothelins and Endothelin Receptor Antagonists: Therapeutic Considerations for a Novel Class of Cardiovascular Drugs
The 21-amino acid peptide endothelin-1 (ET-1) is the predominant isoform of the endothelin peptide family, which includes ET-2… 
Highly Cited
1998
Highly Cited
1998
Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells…
Endothelial dysfunction associated with atherosclerosis has been attributed to alterations in the L-arginine-nitric oxide (NO… 
Highly Cited
1996
Highly Cited
1996
Inhibition of myocardial endothelin pathway improves long-term survival in heart failure
OCCLUSION of the diseased coronary artery in humans causes acute myocardial infarction, survivors of which have a high risk for… 
Highly Cited
1994
Highly Cited
1994
Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1
The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient… 
Highly Cited
1994
Highly Cited
1994
ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
Highly Cited
1993
Highly Cited
1993
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.
BACKGROUND Pulmonary hypertension is characterized by an increase in vascular tone or an abnormal proliferation of muscle cells… 
Highly Cited
1992
Highly Cited
1992
Plasma Endothelin Correlates With the Extent of Pulmonary Hypertension in Patients With Chronic Congestive Heart Failure
BackgroundEndothelin is a family of potent vasoconstrictor peptides of vascular endothelial origin. Although it has been proposed… 
Review
1991
Review
1991
Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?
OBJECTIVE To explore the role of endothelin-1, a potent endothelial-derived vasoconstrictor peptide, in pulmonary hypertension… 
Highly Cited
1990
Highly Cited
1990
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
ENDOTHELIN-1 was initially identified as a 21-residue potent vasoconstrictor peptide produced by vascular endothelial cells, but… 
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