Skip to search form
Skip to main content
Skip to account menu
Semantic Scholar
Semantic Scholar's Logo
Search 210,064,657 papers from all fields of science
Search
Sign In
Create Free Account
Endothelin-1
Known as:
Endothelin-1 [Chemical/Ingredient]
, ET-1
, Endothelin 1
Expand
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the…
Expand
National Institutes of Health
Create Alert
Alert
Related topics
Related topics
30 relations
Narrower (6)
Alexa532-endothelin 1
Preproendothelin-1
Proendothelin (1-38)
endothelin-1 (1-21)
Expand
Cardiac Hypertrophy Pathway
EDN1 gene
Endothelin-1 measurement
Endothelin-2
Expand
Broader (1)
Endothelin
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Effects of the dual endothelin-receptor antagonist bosentan in patients with pulmonary hypertension: a randomised placebocontrolled study
R. Channick
,
G. Simonneau
,
+8 authors
L. Rubin
The Lancet
2001
Corpus ID: 45774066
Highly Cited
2000
Highly Cited
2000
Endothelins and Endothelin Receptor Antagonists: Therapeutic Considerations for a Novel Class of Cardiovascular Drugs
T. Lüscher
,
M. Barton
Circulation
2000
Corpus ID: 14264246
The 21-amino acid peptide endothelin-1 (ET-1) is the predominant isoform of the endothelin peptide family, which includes ET-2…
Expand
Highly Cited
1998
Highly Cited
1998
Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells…
O. Hernández-Perera
,
D. Pérez-Sala
,
+4 authors
S. Lamas
Journal of Clinical Investigation
1998
Corpus ID: 25888949
Endothelial dysfunction associated with atherosclerosis has been attributed to alterations in the L-arginine-nitric oxide (NO…
Expand
Highly Cited
1996
Highly Cited
1996
Inhibition of myocardial endothelin pathway improves long-term survival in heart failure
S. Sakai
,
T. Miyauchi
,
Masahiko Kobayashi
,
I. Yamaguchi
,
K. Goto
,
Y. Sugishita
Nature
1996
Corpus ID: 4261145
OCCLUSION of the diseased coronary artery in humans causes acute myocardial infarction, survivors of which have a high risk for…
Expand
Highly Cited
1994
Highly Cited
1994
Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1
Y. Kurihara
,
H. Kurihara
,
+14 authors
Y. Yazaki
Nature
1994
Corpus ID: 4347818
The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient…
Expand
Highly Cited
1994
Highly Cited
1994
ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
Dong Xu
,
N. Emoto
,
+4 authors
M. Yanagisawa
Cell
1994
Corpus ID: 7872049
Highly Cited
1993
Highly Cited
1993
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.
A. Giaid
,
M. Yanagisawa
,
+7 authors
D. Stewart
New England Journal of Medicine
1993
Corpus ID: 20036634
BACKGROUND Pulmonary hypertension is characterized by an increase in vascular tone or an abnormal proliferation of muscle cells…
Expand
Highly Cited
1992
Highly Cited
1992
Plasma Endothelin Correlates With the Extent of Pulmonary Hypertension in Patients With Chronic Congestive Heart Failure
R. Cody
,
G. Haas
,
P. Binkley
,
Q. Capers
,
R. Kelley
Circulation
1992
Corpus ID: 975233
BackgroundEndothelin is a family of potent vasoconstrictor peptides of vascular endothelial origin. Although it has been proposed…
Expand
Review
1991
Review
1991
Increased plasma endothelin-1 in pulmonary hypertension: marker or mediator of disease?
D. Stewart
,
R. Levy
,
P. Cernacek
,
D. Langleben
Annals of Internal Medicine
1991
Corpus ID: 38258203
OBJECTIVE To explore the role of endothelin-1, a potent endothelial-derived vasoconstrictor peptide, in pulmonary hypertension…
Expand
Highly Cited
1990
Highly Cited
1990
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
T. Sakurai
,
M. Yanagisawa
,
+4 authors
T. Masaki
Nature
1990
Corpus ID: 4249387
ENDOTHELIN-1 was initially identified as a 21-residue potent vasoconstrictor peptide produced by vascular endothelial cells, but…
Expand
By clicking accept or continuing to use the site, you agree to the terms outlined in our
Privacy Policy
(opens in a new tab)
,
Terms of Service
(opens in a new tab)
, and
Dataset License
(opens in a new tab)
ACCEPT & CONTINUE