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Endothelin-1

Known as: Endothelin-1 [Chemical/Ingredient], ET-1, Endothelin 1 
A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the… Expand
National Institutes of Health

Related topics

Related topics

30 relations

Narrower (6)

Alexa532-endothelin 1Preproendothelin-1Proendothelin (1-38)endothelin-1 (1-21)
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Cardiac Hypertrophy PathwayEDN1 geneEndothelin-1 measurementEndothelin-2
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Broader (1)

Endothelin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Endothelins in cardiovascular biology and therapeutics
Cardiovascular disease is a major contributor to global morbidity and mortality and is the common end point of many chronic… Expand
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Review
2018
Review
2018
Endothelial dysfunction and platelet hyperactivity in type 2 diabetes mellitus: molecular insights and therapeutic strategies
The incidence and prevalence of diabetes mellitus is rapidly increasing worldwide at an alarming rate. Type 2 diabetes mellitus… Expand
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Highly Cited
2000
Highly Cited
2000
Endothelins and Endothelin Receptor Antagonists: Therapeutic Considerations for a Novel Class of Cardiovascular Drugs
The 21-amino acid peptide endothelin-1 (ET-1) is the predominant isoform of the endothelin peptide family, which includes ET-2… Expand
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Highly Cited
1994
Highly Cited
1994
Elevated blood pressure and craniofaclal abnormalities in mice deficient in endothelin-1
The endothelin-1 (ET-1) gene was disrupted in mouse embryonic stem cells by homologous recombination to generate mice deficient… Expand
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Highly Cited
1994
Highly Cited
1994
Clearance of circulating endothelin-1 by ETB receptors in rats.
Exogenous endothelin (ET) is rapidly cleared from the circulation. We investigated which ET receptor subtypes (ETA and ETB… Expand
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Highly Cited
1994
Highly Cited
1994
Contribution of endogenous generation of endothelin-1 to basal vascular tone
Endothelin-1 is an endothelium-derived vasoconstrictor peptide, possibly involved in the pathophysiology of cardiovascular… Expand
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Highly Cited
1994
Highly Cited
1994
Both ETA and ETB receptors mediate contraction to endothelin-1 in human blood vessels.
BACKGROUND Endothelin (ET)-1 has potent vascular effects. Two endothelin receptors have been cloned, namely, the ETA receptor… Expand
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Highly Cited
1994
Highly Cited
1994
ECE-1: A membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1
Endothelin-1 (ET-1), a 21-residue vasoactive peptide, is produced in vascular endothelial cells from the 38-residue inactive… Expand
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Highly Cited
1993
Highly Cited
1993
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.
BACKGROUND Pulmonary hypertension is characterized by an increase in vascular tone or an abnormal proliferation of muscle cells… Expand
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Highly Cited
1990
Highly Cited
1990
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
ENDOTHELIN-1 was initially identified as a 21-residue potent vasoconstrictor peptide produced by vascular endothelial cells, but… Expand
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