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Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic.
TLDR
In the community, systolic dysfunction is frequently present in individuals without recognized CHF and diastolic dysfunction as rigorously defined by comprehensive Doppler techniques is common, often not accompanied by recognizedCHF, and associated with marked increases in all-cause mortality.
Effects of oral tolvaptan in patients hospitalized for worsening heart failure: the EVEREST Outcome Trial.
TLDR
Tolvaptan initiated for acute treatment of patients hospitalized with heart failure had no effect on long-term mortality or heart failure-related morbidity.
Neutral endopeptidase inhibition and the natriuretic peptide system: an evolving strategy in cardiovascular therapeutics.
TLDR
The current knowledge of the use and effects of NEPinh alone or in combination with other therapeutic agents for the treatment of human cardiovascular disease such as HF and hypertension is summarized.
Progression of left ventricular diastolic dysfunction and risk of heart failure.
TLDR
In a population-based cohort undergoing 4 years of follow-up, prevalence of diastolic dysfunction increased and was associated with development of heart failure during 6 years of subsequent follow- up.
Circulating and tissue endothelin immunoreactivity in advanced atherosclerosis.
TLDR
Endothelin may be a marker for arterial vascular disease, whether it participates in the atherogenic process or is merely released from damaged endothelial cells is unclear.
Short-term clinical effects of tolvaptan, an oral vasopressin antagonist, in patients hospitalized for heart failure: the EVEREST Clinical Status Trials.
TLDR
In patients hospitalized with heart failure, oral tolvaptan in addition to standard therapy including diuretics improved many, though not all, heart failure signs and symptoms, without serious adverse events.
Endothelin in human congestive heart failure.
TLDR
The present study establishes for the first time that the elevation of plasma ET in severe human CHF represents principally elevation of big-ET, characteristic of severe CHF and not asymptomatic or mild CHF.
The frequency of familial dilated cardiomyopathy in a series of patients with idiopathic dilated cardiomyopathy.
TLDR
Dilated cardiomyopathy was found to be familial in at least one in five of the patients in this study, a considerably higher percentage than in previous reports.
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