Skip to search formSkip to main contentSkip to account menu

Proendothelin (1-38)

Known as: Endothelin-1, Big, Big Endothelin-1, Endothelin, Big 
A 38 amino acid form of endothelin-1 that results from alternative processing of proendothelin-1.
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Endothelin-1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2004
Highly Cited
2004
5-Fluorouracil induces arterial vasocontractions.
BACKGROUND From 2% to 10% of cancer patients treated with 5-fluorouracil (5-FU) will develop symptomatic cardiotoxicity… 
Highly Cited
2001
Highly Cited
2001
Prognostic evaluation of neurohumoral plasma levels before and during beta-blocker therapy in advanced left ventricular dysfunction.
Highly Cited
2000
Highly Cited
2000
Vascular Matrix Metalloproteinase-2–Dependent Cleavage of Calcitonin Gene-Related Peptide Promotes Vasoconstriction
Matrix metalloproteinase (MMP)-2 has been historically associated with the process of vascular remodeling through the cleavage of… 
Highly Cited
1997
Highly Cited
1997
Anatomic heterogeneity of vascular aging: role of nitric oxide and endothelin.
We investigated the effects of aging, a cardiovascular risk factor, on vascular function with regard to endothelial nitric oxide… 
Review
1996
Review
1996
Molecular pharmacology of endothelin converting enzymes.
Highly Cited
1995
Highly Cited
1995
Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance.
We sought to examine mechanisms responsible for increased vasoconstriction that occurs during development of nitroglycerin… 
Highly Cited
1994
Highly Cited
1994
Cloning and functional expression of endothelin-converting enzyme from rat endothelial cells.
Endothelin (ET) is a 21-residue potent vasoconstrictive peptide produced by vascular endothelial cells and formed from its… 
Highly Cited
1991
Highly Cited
1991
Contribution of endogenous endothelin to the extension of myocardial infarct size in rats.
Pathophysiological roles of endogenous endothelin have been studied from the viewpoint of its contribution to the extension of… 
Highly Cited
1990
Highly Cited
1990
A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: comparison of levels in patients with essential hypertension and normotensive control subjects.
1. A radioimmunoassay has been developed for measuring endothelin-like immunoreactivity in human plasma using an antibody raised… 
Highly Cited
1989
Highly Cited
1989
Conversion of Big Endothelin‐1 to 21‐Residue Endothelin‐1 Is Essential for Expression of Full Vasoconstrictor Activity: Structure‐Activity Relationships of Big Endothelin‐1
Summary The vasoconstrictor activities of porcine big endothelin-1 (big ET-1), a 39-residue intermediate predicted from cDNA… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)