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A novel potent vasoconstrictor peptide produced by vascular endothelial cells
Cloning and sequencing of preproendothelin complementary DNA shows that mature endothelin is generated through an unusual proteolytic processing, and regional homologies to a group of neurotoxins suggest that endothelins is an endogenous modulator of voltage-dependent ion channels. Expand
Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor
The cloning of a complementary DNA encoding one subtype belonging to the superf amily of G protein-coupled receptors is reported, indicating that this cDNA encodes a 'nonselective' subtype of the receptor which is different from the vascular smooth muscle receptor. Expand
The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes.
Three distinct human endothelin-related genes were cloned by screening a genomic DNA library under a low hybridization stringency with a synthetic oligonucleotide probe encoding a portion of the endotheli sequence, suggesting the possible existence of endothelins receptor subtypes. Expand
Expression of endothelin-1 in the lungs of patients with pulmonary hypertension.
Preliminary results suggest that pulmonary hypertension is associated with the increased expression of endothelin-1 in vascular endothelial cells, suggesting that the local production of endethelin- 1 may contribute to the vascular abnormalities associated with this disorder. Expand
An endothelial receptor for oxidized low-density lipoprotein
The molecular cloning, using expression cloning strategy, of an Ox-LDL receptor from vascular endothelial cells is reported, which is a membrane protein that belongs structurally to the C-type lectin family, and is expressed in vivo in vascular endothelium and vascular-rich organs. Expand
Pathophysiology of endothelin in the cardiovascular system.
The results suggest that the interference with endothelin pathway either by receptor blockade or by inhibition ofendothelin converting enzyme may provide novel therapeutic drugs strategies for multiple disease states. Expand
Historical review: Endothelin.
  • T. Masaki
  • Biology, Medicine
  • Trends in pharmacological sciences
  • 1 April 2004
The field of molecular biology has provided valuable information about ET, including evidence that the ET system plays important roles in the early development of the neural crest and, thus, in the formation of organs. Expand
The human preproendothelin-1 gene. Complete nucleotide sequence and regulation of expression.
The whole length of the human preproendothelin-1 gene and the corresponding cDNA and the complete nucleotide sequences are cloned and suggest that the regulation of expression of PPET-1 mRNA may be mediated in part by these sequence elements. Expand
International Union of Pharmacology nomenclature of endothelin receptors.
Results of many pharmacological and ligand-binding expemiments have suggested the existence of multiple subtypes of ET, and these diverse responses to ETs appear to be mediated by specific receptors. Expand
Both hypertrophic and dilated cardiomyopathies are caused by mutation of the same gene, delta-sarcoglycan, in hamster: an animal model of disrupted dystrophin-associated glycoprotein complex.
CM hamster is identified as a valuable animal model for studying the function of delta-SG in vivo but also provides a genetic target for diagnosis and treatment of human CM. Expand