Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance.

@article{Mnzel1995EvidenceFA,
  title={Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance.},
  author={Thomas F. M{\"u}nzel and Adel Giaid and Stefan Kurz and David J. Stewart and David G Harrison},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 11},
  pages={5244-8}
}
We sought to examine mechanisms responsible for increased vasoconstriction that occurs during development of nitroglycerin tolerance. Rabbits were treated for 3 days with nitroglycerin patches (0.4 mg/hr), and their aortic segments were studied in organ chambers. This treatment resulted in attenuated in vitro relaxations to nitroglycerin and increased contractile sensitivity to angiotensin II, serotonin, phenylephrine, KCl, and a direct activator of protein kinase C, the phorbol ester phorbol… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 72 extracted citations

Similar Papers

Loading similar papers…