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IRAK4 protein, human

Known as: interleukin-1 receptor-associated kinase 4 protein, human, NY-REN-64 antigen, human, IRAK4 
Widely expressed (strongest in kidney and liver) by human IRAK4 Gene, 460-aa Interleukin-1 Receptor-Associated Kinase 4 contains (like IRAK1, IRAK2… 
National Institutes of Health

Related topics

Related topics

7 relations
IRAK4 geneProtein KinasesProtein phosphorylationSignal Transduction

Broader (2)

Interleukin-1 Receptor-Associated Kinase 4Interleukin-1 Receptor-Associated Kinases

Papers overview

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2019
2019
Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor–associated kinase 4 (IRAK4)
Interleukin-1 receptor–associated kinase 4 (IRAK4) is a key player in innate immune and inflammatory responses, performing a… 
2017
2017
Constitutive IRAK 4 Activation Underlies Poor Prognosis and Chemoresistance in Pancreatic Ductal Adenocarcinoma
Purpose: Aberrant activation of the NF-kB transcription factors underlies the aggressive behavior and poor outcome of pancreatic… 
2016
2016
Abstract 346: Potential role for R191, potent and selective IRAK4 kinase inhibitor, in treatment of hematologic malignancies
Recent advances in genome sequencing and tumor proteome and transcriptome analysis uncovered a key role for MyD88-dependent Toll… 
2016
2016
A benzenediamine derivate FC-99 attenuates lupus nephritis in MRL/lpr mice via inhibiting myeloid dendritic cell-secreted BAFF.
Myeloid dendritic cells (DCs) can produce B-cell-activating factor (BAFF) that modulates survival and differentiation of B cells… 
2016
2016
Revisiting the Role of TLR/IRAK Signaling and its Therapeutic Potential in Cancer
Interleukin-1 receptor-associated kinase (IRAK) family consistsof four members: IRAK1, IRAK2, IRAK3/M and IRAK4. They are key… 
2015
2015
IRAK4 deficiency promotes cardiac remodeling induced by pressure overload.
BACKGROUND Interluekin1 receptor-associated kinase-4 (IRAK4) plays an essential role in the innate immune system. The aim of this… 
2014
2014
The Role of Interleukin-1 Receptor-Associated Kinases in Vogt-Koyanagi-Harada Disease
Purpose To explore whether IRAK1 and IRAK4 are involved in the pathogenesis of Vogt-Koyanagi-Harada (VKH) disease. Methods Thirty… 
2014
2014
Liver Abscess Complicated by Diaphragm Perforation and Pleural Empyema Leads to the Discovery of Interleukin-1 Receptor-associated Kinase 4 Deficiency
Interleukin-1 receptor-associated kinase 4 (IRAK-4) deficiency predisposes to severe invasive bacterial infections in infancy and… 
2012
2012
IRAK4 Kinase As A Novel Therapeutic Target in the ABC Subtype of Diffuse Large B Cell Lymphoma
Abstract 62 Activating mutations of MyD88, particularly L265P, occur in about 30% of activated B cell-like diffuse large B cell… 
2007
2007
Role of IRAK4 and IRF3 in the control of intracellular infection with Chlamydia pneumoniae
TLR signal transduction involves a MyD88‐mediated pathway, which leads to recruitment of the IL‐1 receptor (IL‐1R)‐associated… 
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