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IRAK4 protein, human

Known as: interleukin-1 receptor-associated kinase 4 protein, human, NY-REN-64 antigen, human, IRAK4 
Widely expressed (strongest in kidney and liver) by human IRAK4 Gene, 460-aa Interleukin-1 Receptor-Associated Kinase 4 contains (like IRAK1, IRAK2… 
National Institutes of Health

Related topics

Related topics

7 relations
IRAK4 geneProtein KinasesProtein phosphorylationSignal Transduction

Broader (2)

Interleukin-1 Receptor-Associated Kinase 4Interleukin-1 Receptor-Associated Kinases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
The impact of cancer-associated fibroblasts on major hallmarks of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) constitutes one of the most challenging lethal tumors and has a very poor prognosis. In… 
Highly Cited
2017
Highly Cited
2017
Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation
Highly Cited
2017
Highly Cited
2017
The mechanism of activation of IRAK1 and IRAK4 by interleukin-1 and Toll-like receptor agonists
We have developed the first assays that measure the protein kinase activities of interleukin-1 receptor-associated kinase 1… 
Highly Cited
2014
Highly Cited
2014
MicroRNA-302b augments host defense to bacteria by regulating inflammatory responses via feedback to TLR/IRAK4 circuits
MicroRNAs (miRNAs) have been implicated in a spectrum of physiological and pathological conditions, including immune responses… 
Highly Cited
2011
Highly Cited
2011
Endotoxin Tolerance Impairs IL-1 Receptor-Associated Kinase (IRAK) 4 and TGF-β-activated Kinase 1 Activation, K63-linked Polyubiquitination and Assembly of IRAK1, TNF Receptor-associated Factor 6…
Endotoxin tolerance reprograms Toll-like receptor 4 responses by impairing LPS-elicited production of pro-inflammatory cytokines… 
Highly Cited
2009
Highly Cited
2009
TLR4 signaling induced by lipopolysacharide or paclitaxel regulates tumor survival and chemoresistance in ovarian cancer
Toll-like receptors (TLRs) expressed on immune cells trigger inflammatory responses. TLRs are also expressed on ovarian cancer… 
Highly Cited
2009
Highly Cited
2009
Identification of Critical Residues of the MyD88 Death Domain Involved in the Recruitment of Downstream Kinases*
MyD88 couples the activation of the Toll-like receptors and interleukin-1 receptor superfamily with intracellular signaling… 
Highly Cited
2006
Highly Cited
2006
The C-terminal Activating Region 2 of the Epstein-Barr Virus-encoded Latent Membrane Protein 1 Activates NF-κB through TRAF6 and TAK1*
Epstein-Barr virus (EBV)-encoded latent membrane protein 1 (LMP1) is oncogenic and indispensable for EBV-mediated B cell… 
Highly Cited
2005
Highly Cited
2005
A Novel Splice Variant of Interleukin-1 Receptor (IL-1R)-Associated Kinase 1 Plays a Negative Regulatory Role in Toll/IL-1R-Induced Inflammatory Signaling
ABSTRACT The interleukin-1 (IL-1) receptor-associated kinase 1 (IRAK1) is a member of the IRAK kinase family that plays a pivotal… 
Highly Cited
2004
Highly Cited
2004
IRAK4 Kinase Activity Is Redundant for Interleukin-1 (IL-1) Receptor-associated Kinase Phosphorylation and IL-1 Responsiveness*
Interleukin-1 (IL-1) stimulation leads to the recruitment of interleukin-1 receptor-associated kinase (IRAK) to the IL-1 receptor… 
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