IRAK4 protein, human

Known as: interleukin-1 receptor-associated kinase 4 protein, human, NY-REN-64 antigen, human, IRAK4 
Widely expressed (strongest in kidney and liver) by human IRAK4 Gene, 460-aa Interleukin-1 Receptor-Associated Kinase 4 contains (like IRAK1, IRAK2… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Innate immune response is the first defense against pathogens via recognition by various conserved pattern recognition receptors… (More)
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Highly Cited
2011
Highly Cited
2011
The activated B-cell-like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL) remains the least curable form of this… (More)
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2011
2011
TLRs mediate host defense against microbial pathogens by eliciting production of inflammatory mediators and activating expression… (More)
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Highly Cited
2010
Highly Cited
2010
MyD88, IRAK4 and IRAK2 are critical signalling mediators of the TLR/IL1-R superfamily. Here we report the crystal structure of… (More)
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Highly Cited
2007
Highly Cited
2007
IRAK4 is a member of IL-1 receptor (IL-1R)-associated kinase (IRAK) family and has been shown to play an essential role in Toll… (More)
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Highly Cited
2007
Highly Cited
2007
MyD88 is an adaptor protein, which plays an essential role in the intracellular signaling elicited by IL-1R and several TLRs… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND About 2% of childhood episodes of invasive pneumococcal disease (IPD) are recurrent, and most remain unexplained… (More)
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2006
2006
Tolerance to bacterial cell-wall components may represent an essential regulatory mechanism during bacterial infection. We have… (More)
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2004
2004
Interleukin-1 (IL-1) stimulation leads to the recruitment of interleukin-1 receptor-associated kinase (IRAK) to the IL-1 receptor… (More)
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2003
2003
Epstein-Barr virus latent membrane protein 1 (LMP1) activation of NF-kappaB is critical for Epstein-Barr virus-infected B… (More)
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