Interleukin-1 Receptor-Associated Kinases

Known as: IRAK Kinases, Interleukin-1 Receptor-Associated Kinases [Chemical/Ingredient], IL 1 Receptor Associated Kinase 
A family of intracellular signaling kinases that were identified by their ability to signal from the activated INTERLEUKIN-1 RECEPTORS. Signaling… (More)
National Institutes of Health

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IRAK1 protein, humanIRAK3 protein, humanIRAK4 DeficiencyIRAK4 protein, human
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In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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Papers overview

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Review
2010
Review
2010
The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling.
The interleukin receptor-associated kinase (IRAK) family are involved in regulating Toll-like receptor (TLR) and interleukin-1… (More)
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Highly Cited
2010
Highly Cited
2010
Regulation of Tau Pathology by the Microglial Fractalkine Receptor
Aggregates of the hyperphosphorylated microtubule-associated protein tau (MAPT) are an invariant neuropathological feature of… (More)
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2009
2009
Interleukin-1 receptor-associated kinase 2 is critical for lipopolysaccharide-mediated post-transcriptional control.
IRAK2, a member of the interleukin-1 receptor-associated kinase (IRAK) family, has been implicated in Toll-like receptor (TLR… (More)
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Highly Cited
2006
Highly Cited
2006
Mature-onset obesity in interleukin-1 receptor I knockout mice.
Interleukin-1 (IL-1) is a major mediator of inflammation that exerts its biological activities through the IL-1 type I receptor… (More)
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Highly Cited
2006
Highly Cited
2006
Tollip regulates proinflammatory responses to interleukin-1 and lipopolysaccharide.
Activation of interleukin-1 (IL-1) receptor (IL-1R), Toll-like receptor 2 (TLR2), and TLR4 triggers NF-kappaB and mitogen… (More)
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Highly Cited
2006
Highly Cited
2006
Nox2 and Rac1 regulate H2O2-dependent recruitment of TRAF6 to endosomal interleukin-1 receptor complexes.
Reactive oxygen species (ROS) generated by NADPH oxidases (Nox) have been implicated in the regulation of signal transduction… (More)
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Highly Cited
2004
Highly Cited
2004
Sequential autophosphorylation steps in the interleukin-1 receptor-associated kinase-1 regulate its availability as an adapter in interleukin-1 signaling.
The interleukin-1 receptor-associated kinase 1 (IRAK-1) is an important adapter in the signaling complex of the Toll/interleukin… (More)
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Highly Cited
2002
Highly Cited
2002
Gram-negative flagellin-induced self-tolerance is associated with a block in interleukin-1 receptor-associated kinase release from toll-like receptor 5.
Flagellin from a number of Gram-negative bacteria induces cytokine and nitric oxide production by inflammatory cell types. In… (More)
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Highly Cited
2001
Highly Cited
2001
Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway.
Interleukin-1 (IL-1) is a proinflammatory cytokine that recognizes a surface receptor complex and generates multiple cellular… (More)
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Highly Cited
1999
Highly Cited
1999
IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family.
The interleukin-1 receptor-associated kinase (IRAK) was first described as a signal transducer for interleukin-1 (IL-1) and has… (More)
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