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Interleukin-1 Receptor-Associated Kinases

Known as: IRAK Kinases, Interleukin-1 Receptor-Associated Kinases [Chemical/Ingredient], IL 1 Receptor Associated Kinase 
A family of intracellular signaling kinases that were identified by their ability to signal from the activated INTERLEUKIN-1 RECEPTORS. Signaling… Expand
National Institutes of Health

Related topics

Related topics

16 relations

Narrower (9)

IRAK1 protein, humanIRAK3 protein, humanIRAK4 DeficiencyIRAK4 protein, human
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In BloodProcess of secretionantagonists & inhibitorsaspects of radiation effects
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Inhibition of interleukin-1 receptor-associated kinase 1 (IRAK1) as a therapeutic strategy
Interleukin-1 receptor-associated kinases (IRAK1, IRAK2, IRAK3 [IRAK-M], and IRAK4) are serine-threonine kinases involved in toll… Expand
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Review
2010
Review
2010
The interleukin-1 receptor-associated kinases: critical regulators of innate immune signalling.
The interleukin receptor-associated kinase (IRAK) family are involved in regulating Toll-like receptor (TLR) and interleukin-1… Expand
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Highly Cited
2010
Highly Cited
2010
Regulation of Tau Pathology by the Microglial Fractalkine Receptor
Aggregates of the hyperphosphorylated microtubule-associated protein tau (MAPT) are an invariant neuropathological feature of… Expand
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Highly Cited
2010
Highly Cited
2010
Interleukin-1 blockade with anakinra to prevent adverse cardiac remodeling after acute myocardial infarction (Virginia Commonwealth University Anakinra Remodeling Trial [VCU-ART] Pilot study).
Acute myocardial infarction (AMI) initiates an intense inflammatory response in which interleukin-1 (IL-1) plays a central role… Expand
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Highly Cited
2010
Highly Cited
2010
A polymorphism in the 3'-UTR of interleukin-1 receptor-associated kinase (IRAK1), a target gene of miR-146a, is associated with rheumatoid arthritis susceptibility.
OBJECTIVES Rheumatoid arthritis (RA) is a chronic inflammatory disorder with many genetic factors predisposing to disease… Expand
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Highly Cited
2004
Highly Cited
2004
Sequential Autophosphorylation Steps in the Interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling*
The interleukin-1 receptor-associated kinase 1 (IRAK-1) is an important adapter in the signaling complex of the Toll/interleukin… Expand
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Review
2003
Review
2003
TRAF6, a molecular bridge spanning adaptive immunity, innate immunity and osteoimmunology
  • H. Wu, J. Arron
  • BioEssays : news and reviews in molecular…
  • 2003
    • Corpus ID: 28521713
Tumor necrosis factor (TNF) receptor associated factor 6 (TRAF6) is a crucial signaling molecule regulating a diverse array of… Expand
Highly Cited
1999
Highly Cited
1999
IRAK-M Is a Novel Member of the Pelle/Interleukin-1 Receptor-associated Kinase (IRAK) Family*
The interleukin-1 receptor-associated kinase (IRAK) was first described as a signal transducer for interleukin-1 (IL-1) and has… Expand
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Highly Cited
1992
Highly Cited
1992
Effect of interleukin-1 (IL-1) blockade on cytokine synthesis: I. IL-1 receptor antagonist inhibits IL-1-induced cytokine synthesis and blocks the binding of IL-1 to its type II receptor on human…
Interleukin-1 (IL-1) induces IL-1, tumor necrosis factor alpha (TNF alpha), and IL-6 gene expression and synthesis in a variety… Expand
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Highly Cited
1988
Highly Cited
1988
Interleukin-1 is an astroglial growth factor in the developing brain
The immunomodulator interleukin-1 (IL-1) is found to be an astroglial growth factor during development of the mammalian brain. In… Expand
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