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IRAK4 gene

Known as: NY-REN-64, interleukin 1 receptor associated kinase 4, IRAK4 
This gene plays a role in signal transduction and the immune response.
National Institutes of Health

Related topics

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4 relations
IRAK4 protein, humanInterleukin-1 Receptor-Associated Kinase 4Protein phosphorylationSignal Transduction

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Abstract LB-272: KYM-001, a first-in-class oral IRAK4 protein degrader, induces tumor regression in xenograft models of MYD88-mutant ABC DLBCL alone and in combination with BTK inhibition
Purpose: This work assessed the antitumor activity of selective small molecule IRAK4 degraders in human ABC DLBCL cell lines in… 
2018
2018
IRAK4 activity controls immune responses to intracellular bacteria Listeria monocytogenes and Mycobacterium smegmatis
IL‐1 receptor‐associated kinase (IRAK) 4 is a central enzyme of the TLR pathways. This study tested the hypothesis that IRAK4… 
2018
2018
Upregulated IRAK1 and IRAK4 promoting the production of IFN-γ and IL-17 in Behcet’s disease
PurposeTo investigate the expression and function of IRAK1 and IRAK4 involved in the development of Behcet’s disease… 
2017
2017
Molecular cloning, structural modeling, and expression analysis of MyD88 and IRAK4 of golden pompano (Trachinotus ovatus)
2016
2016
Alternative Splice Variants of IRAK4 That Activate Innate Immune Signaling Are Associated with U2AF1 Mutations in Myelodysplastic Syndrome and Acute Myeloid Leukemia
2015
2015
Rare Variants in MYD88, IRAK4 and IKBKG and Susceptibility to Invasive Pneumococcal Disease: A Population-Based Case-Control Study
Although rare variants within the Toll-like receptor signalling pathway genes have been found to underlie human primary… 
2013
2013
Effect Of MYD88 Mutation In CLL On IRAK4 and BTK Inhibition In Vitro
Recent work in CLL and other lymphoproliferative disorders has established the importance of somatic mutations in the… 
2012
2012
Membrane-Bound Toll-Like Receptors are Overexpressed in Peripheral Blood and Synovial Fluid Mononuclear Cells of Enthesitis-Related Arthritis Category of Juvenile Idiopathic Arthritis (JIA–ERA…
We examined expression and function of TLRs in enthesitis-related arthritis (ERA) patients. RNA levels of TLR1, TLR3, and TLRs 5… 
Highly Cited
2009
Highly Cited
2009
Identification of Novel Genes That Mediate Innate Immunity Using Inbred Mice
Innate immunity is the first line of defense against microbial infections. Although polymorphisms in toll-like receptors (TLRs… 
2007
2007
Role of IRAK4 and IRF3 in the control of intracellular infection with Chlamydia pneumoniae
TLR signal transduction involves a MyD88‐mediated pathway, which leads to recruitment of the IL‐1 receptor (IL‐1R)‐associated… 
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