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TLR4 mutations are associated with endotoxin hyporesponsiveness in humans
These findings provide the first genetic evidence that common mutations in TLR4 are associated with differences in LPS responsiveness in humans, and demonstrate that gene-sequence changes can alter the ability of the host to respond to environmental stress.
Human microsporidial infections
- R. Weber, R. Bryan, D. Schwartz, R. Owen
- Biology, MedicineClinical Microbiology Reviews
- 1 October 1994
Progress is being made with respect to in vitro propagation of microsporidia, which is crucial for developing antimicrosporidial drugs, and molecular techniques are being developed for diagnostic purposes, taxonomic classification, and analysis of phylogenetic relationships.
Loss-of-Function Mutation in Tryptophan Hydroxylase-2 Identified in Unipolar Major Depression
Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis
The results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs.
Clinical and pathologic features of familial interstitial pneumonia.
- M. Steele, M. Speer, D. Schwartz
- MedicineAmerican journal of respiratory and critical care…
- 1 November 2005
It is suggested that FIP may be caused by an interaction between a specific environmental exposure and a gene (or genes) that predisposes to the development of several subtypes of idiopathic interstitial pneumonia.
A common MUC5B promoter polymorphism and pulmonary fibrosis.
The findings suggest that dysregulated MUC5B expression in the lung may be involved in the pathogenesis of pulmonary fibrosis, and a common polymorphism in the promoter of M UC5B is associated with familial interstitial pneumonia and idiopathic pulmonary fibrot.
Protection from Experimental Asthma by an Endogenous Bronchodilator
It is reported that, following allergen challenge, wild-type mice exhibiting airway hyperresponsivity have increased airway levels of the enzyme GSNO reductase (GSNOR) and are depleted of lung S-nitrosothiols (SNOs).
An Analysis of 38 Pregnant Women with COVID-19, Their Newborn Infants, and Maternal-Fetal Transmission of SARS-CoV-2: Maternal Coronavirus Infections and Pregnancy Outcomes.
- D. Schwartz
- MedicineArchives of pathology & laboratory medicine
- 17 March 2020
At this point in the global pandemic of COVID-19 infection there is no evidence that SARS-CoV-2 undergoes intrauterine or transplacental transmission from infected pregnant women to their fetuses, and analysis of additional cases is necessary to determine if this remains true.
Toll-like receptors in the pathogenesis of human disease
A comparison of the incidence of disease among people having different polymorphisms in genes that participate in TLR signaling shows that TLR function affects several diseases, including sepsis, immunodeficiencies, atherosclerosis and asthma.
Heterozygosity for a surfactant protein C gene mutation associated with usual interstitial pneumonitis and cellular nonspecific interstitial pneumonitis in one kindred.
- A. Q. Thomas, K. Lane, J. Loyd
- Medicine, BiologyAmerican journal of respiratory and critical care…
- 1 May 2002
It is shown that an SFTPC mutation segregates with the pulmonary fibrosis phenotype in this kindred and may cause type II cellular injury.