• Publications
  • Influence
Clonal relationships between invasive and carriage Streptococcus pneumoniae and serotype- and clone-specific differences in invasive disease potential.
By use of multilocus sequence typing, Streptococcus pneumoniae isolates causing invasive disease (n=150) were compared with those from nasopharyngeal carriage (n=351) among children in Oxford. TheExpand
  • 596
  • 47
Whole-genome sequencing to delineate Mycobacterium tuberculosis outbreaks: a retrospective observational study
Summary Background Tuberculosis incidence in the UK has risen in the past decade. Disease control depends on epidemiological data, which can be difficult to obtain. Whole-genome sequencing can detectExpand
  • 587
  • 39
  • PDF
Diverse sources of C. difficile infection identified on whole-genome sequencing.
BACKGROUND It has been thought that Clostridium difficile infection is transmitted predominantly within health care settings. However, endemic spread has hampered identification of precise sources ofExpand
  • 488
  • 27
  • PDF
A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
Toll-like receptors (TLRs) and members of their signaling pathway are important in the initiation of the innate immune response to a wide variety of pathogens. The adaptor protein Mal (also known asExpand
  • 453
  • 27
  • PDF
Transforming clinical microbiology with bacterial genome sequencing
Whole-genome sequencing of bacteria has recently emerged as a cost-effective and convenient approach for addressing many microbiological questions. Here, we review the current status of clinicalExpand
  • 560
  • 24
  • PDF
Temporal and geographic stability of the serogroup-specific invasive disease potential of Streptococcus pneumoniae in children.
A meta-analysis study design was used to analyze 7 data sets of invasive and carriage pneumococcal isolates recovered from children, to determine whether invasive disease potential differs for eachExpand
  • 327
  • 23
Capsular serotype-specific attack rates and duration of carriage of Streptococcus pneumoniae in a population of children.
BACKGROUND The relative invasiveness rates (attack rates) of Streptococcus pneumoniae of different capsular serotypes in children are not known. Estimates of capsular serotype invasivenessExpand
  • 252
  • 23
Fidaxomicin versus vancomycin for infection with Clostridium difficile in Europe, Canada, and the USA: a double-blind, non-inferiority, randomised controlled trial.
BACKGROUND Infection with Clostridium difficile is the primary infective cause of antibiotic-associated diarrhoea. We aimed to compare efficacy and safety of fidaxomicin and vancomycin to treatExpand
  • 545
  • 22
Differences in outcome according to Clostridium difficile testing method: a prospective multicentre diagnostic validation study of C difficile infection
Summary Background Diagnosis of Clostridium difficile infection is controversial because of many laboratory methods, compounded by two reference methods. Cytotoxigenic culture detects toxigenic CExpand
  • 346
  • 21
  • PDF
Impact of meningococcal serogroup C conjugate vaccines on carriage and herd immunity.
BACKGROUND In 1999, meningococcal serogroup C conjugate (MCC) vaccines were introduced in the United Kingdom for those under 19 years of age. The impact of this intervention on asymptomatic carriageExpand
  • 403
  • 19
  • PDF