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ASK1 is essential for JNK/SAPK activation by TRAF2.
TLDR
It is shown that ASK1 interacts with members of the TRAF family and is activated by TRAF2, TRAF5, and TRAF6 overexpression and is a mediator of TRAf2-induced JNK activation.
The atypical PKC‐interacting protein p62 channels NF‐κB activation by the IL‐1–TRAF6 pathway
TLDR
It is demonstrated that the inhibition of the aPKCs or the down‐regulation of p62 severely abrogates NF‐κB activation by IL‐1 and TRAF6, suggesting that both proteins are critical intermediaries in this pathway.
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
TLDR
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms.
NF‐κB inhibits TNF‐induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death
TLDR
It is demonstrated here that TNF stimulation leads to accumulation of reactive oxygen species (ROS), which is essential for prolonged mitogen‐activated protein kinase (MAPK) activation and cell death.
SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex
TLDR
Deletion of SHARPIN drastically reduced the amount of LUBAC, which resulted in attenuated TNF-α- and CD40-mediated activation of NF-κB in mouse embryonic fibroblasts (MEFs) or B cells from cpdm mice, and strongly suggest the involvement of LubAC-induced NF-σκB activation in various disorders.
NF-kappaB RelA phosphorylation regulates RelA acetylation.
TLDR
Findings indicate that the acetylation of RelA at lysine 310 is importantly regulated by prior phosphorylation of serines 276 and 536, and such phosphorylated and acetylated forms ofrelA display enhanced transcriptional activity.
A critical role of RICK/RIP2 polyubiquitination in Nod-induced NF-kappaB activation.
TLDR
RICK polyubiquitination links TAK1 to IKK complexes, a critical step in Nod1/Nod2-mediated NF-kappaB activation, and is shown to be essential for RICK-mediated IKK activation and cytokine/chemokine secretion.
Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1.
TLDR
Results indicate that Nik and MEKK1 independently activate the IKK complex and that the kinase activities of IKKalpha and IKKbeta are differentially regulated by two upstream kinases, NIK andMEKK1, which are responsive to distinct stimuli.
Molecular Basis for Hematopoietic/Mesenchymal Interaction during Initiation of Peyer's Patch Organogenesis
TLDR
It is shown that PP organogenesis is initiated at sites containing IL-7Rα+ lymphoid cells and vascular cell adhesion molecule (VCAM)-1/intercellular adhesion molecules (ICAM-1) expressing nonlymphoid elements and chemokine signals, which are mesenchymal cells that are activated by lymphoids cells through the LTβR to express adhesion Molecule and Chemokines.
A critical role of RICK/RIP2 polyubiquitination in Nod‐induced NF‐κB activation
TLDR
RICK polyubiquitination links TAK1 to IKK complexes, a critical step in Nod1/Nod2‐mediated NF‐κB activation, and is shown to be essential for RICK‐mediated IKK activation and cytokine/chemokine secretion.
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