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The RNA-binding protein Sam68 modulates the alternative splicing of Bcl-x
The RNA-binding protein Sam68 is involved in apoptosis, but its cellular mRNA targets and its mechanism of action remain unknown. We demonstrate that Sam68 binds the mRNA for Bcl-x and affects itsExpand
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Sam68 regulates EMT through alternative splicing–activated nonsense-mediated mRNA decay of the SF2/ASF proto-oncogene
Expression levels of SF2/ASF are controlled by Sam68 mediated activation of splicing-induced mRNA decay.
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Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition.
Oocyte maturation, fertilization, and early embryonic development occur in the absence of gene transcription. Therefore, it is critical to understand at a global level the post-transcriptional eventsExpand
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EMT and stemness: flexible processes tuned by alternative splicing in development and cancer progression
Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well as with generation and maintenance of cancer stem cells. In this way, EMT contributes to tumor invasion,Expand
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Tr‐kit‐induced resumption of the cell cycle in mouse eggs requires activation of a Src‐like kinase
Microinjection in mouse eggs of tr‐kit, a truncated form of the c‐kit tyrosine kinase present in mouse spermatozoa, causes resumption of meiosis through activation of phospholipase Cγ1 (PLCγ1) andExpand
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Expression of a truncated form of the c-Kit tyrosine kinase receptor and activation of Src kinase in human prostatic cancer.
A truncated form of the c-Kit tyrosine kinase receptor, originally identified in mouse haploid germ cells, is aberrantly expressed in human cancer cell lines of various origin. This alternativeExpand
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Alternative splicing of the cyclin D1 proto-oncogene is regulated by the RNA-binding protein Sam68.
Human cyclin D1 is expressed as two isoforms derived by alternate RNA splicing, termed D1a and D1b, which differ for the inclusion of intron 4 in the D1b mRNA. Both isoforms are frequentlyExpand
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Mutational analysis suggests that activation of the yeast pheromone response mitogen-activated protein kinase pathway involves conformational changes in the Ste5 scaffold protein.
Ste5 is essential for pheromone response and binds components of a mitogen-activated protein kinase (MAPK) cascade: Ste11 (MEKK), Ste7 (MEK), and Fus3 (MAPK). Pheromone stimulation releasesExpand
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Sam68 regulates translation of target mRNAs in male germ cells, necessary for mouse spermatogenesis
Sam68 is a KH-type RNA-binding protein involved in several steps of RNA metabolism with potential implications in cell differentiation and cancer. However, its physiological roles are still poorlyExpand
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Dynamic Regulation of Histone H3 Methylation at Lysine 4 in Mammalian Spermatogenesis1
Abstract Spermatogenesis is a highly complex cell differentiation process that is governed by unique transcriptional regulation and massive chromatin alterations, which are required for meiosis andExpand
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