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IRAK1 wt Allele

Known as: IRAK, Interleukin-1 Receptor-Associated Kinase 1 wt Allele, pelle 
Human IRAK1 wild-type allele is located within Xq28 and is approximately 9 kb in length. This allele, which encodes interleukin-1 receptor-associated… 
National Institutes of Health

Related topics

Related topics

12 relations
ApoptosisBeta-Catenin Accumulation PathwayIL1R Signaling PathwayNFKB Signaling Pathway

Broader (1)

IRAK1 gene

Papers overview

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Highly Cited
2011
Highly Cited
2011
Structure-Function Similarities between a Plant Receptor-like Kinase and the Human Interleukin-1 Receptor-associated Kinase-4*
Phylogenetic analysis has previously shown that plant receptor-like kinases (RLKs) are monophyletic with respect to the kinase… 
Highly Cited
2002
Highly Cited
2002
Regulation of IL-1 Receptor-Associated Kinases by Lipopolysaccharide1
IL-1R-associated kinase (IRAK) plays a pivotal role in IL-1R/Toll-like receptor (TLR)-mediated signaling and NF-κB activation… 
Highly Cited
2002
Highly Cited
2002
Molecular evolution of the NF-κB signaling system
Abstract. The mechanisms of innate immunity in vertebrates show certain overall resemblances to immune mechanisms of insects. Two… 
Highly Cited
2000
Highly Cited
2000
Tolerance and sensitization to endotoxin in Kupffer cells caused by acute ethanol involve interleukin-1 receptor-associated kinase.
Ethanol changes sensitivity of Kupffer cells to endotoxin. Here, the hypothesis that interleukin-1 receptor-associated kinase… 
Highly Cited
2000
Highly Cited
2000
The Drosophila Tumor Necrosis Factor Receptor-associated Factor-1 (DTRAF1) Interacts with Pelle and Regulates NFκB Activity*
A member of the tumor necrosis factor (TNF) receptor-associated factor (TRAF) family was identified inDrosophila. DTRAF1 contains… 
Highly Cited
1999
Highly Cited
1999
Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB.
Upon interleukin 1 (IL-1) stimulation, the IL-1-receptor (IL-1R)-associated kinase (IRAK) is rapidly recruited to the IL-1R… 
Highly Cited
1998
Highly Cited
1998
Recruitment of Tube and Pelle to signaling sites at the surface of the Drosophila embryo.
A signaling pathway initiated by activation of the transmembrane receptor Toll defines dorsoventral polarity in the Drosophila… 
Highly Cited
1997
Highly Cited
1997
An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators.
A signaling pathway active on the ventral side of the Drosophila embryo defines dorsoventral polarity. A cell surface signal… 
Highly Cited
1997
Highly Cited
1997
An anteroposterior Dorsal gradient in the Drosophila embryo.
Dorsoventral (DV) patterning of the Drosophila embryo is initiated by a broad Dorsal (Dl) nuclear gradient, which is regulated by… 
Highly Cited
1995
Highly Cited
1995
Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos.
Within the Drosophila embryo, tube and the protein kinase pelle transduce an intracellular signal generated by the transmembrane… 
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