• Publications
  • Influence
Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection
The major histocompatibility complex (MHC) loci are known to be highly polymorphic in humans, mice and certain other mammals, with heterozygosity as high as 80–90% (ref. 1). Four different hypothesesExpand
  • 1,825
  • 88
  • PDF
The evolution of functionally novel proteins after gene duplication
  • A. Hughes
  • Biology, Medicine
  • Proceedings of the Royal Society of London…
  • 23 May 1994
A widely cited model of the evolution of functionally novel proteins (here called the model of mutation during non-functionality (MDN model)) holds that, after gene duplication, one gene copy isExpand
  • 878
  • 62
Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection.
  • A. Hughes, M. Nei
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1 February 1989
To study the mechanism of maintenance of polymorphism at major histocompatibility complex (MHC) loci, synonymous and nonsynonymous (amino acid-altering) nucleotide substitutions in the putativeExpand
  • 858
  • 42
Natural selection at major histocompatibility complex loci of vertebrates.
The loci of the vertebrate major histocompatibility complex encode cell-surface glycoproteins that present peptides to T cells. Certain of these loci are highly polymorphic, and the mechanismsExpand
  • 579
  • 37
  • PDF
A genome-wide screen identifies a single β-defensin gene cluster in the chicken: implications for the origin and evolution of mammalian defensins
BackgroundDefensins comprise a large family of cationic antimicrobial peptides that are characterized by the presence of a conserved cysteine-rich defensin motif. Based on the spacing pattern ofExpand
  • 261
  • 27
Phylogenies of Developmentally Important Proteins Do Not Support the Hypothesis of Two Rounds of Genome Duplication Early in Vertebrate History
  • A. Hughes
  • Biology, Medicine
  • Journal of Molecular Evolution
  • 1 May 1999
Abstract. It has been proposed that two rounds of duplication of the entire genome (polyploidization) occurred early in vertebrate history (the 2R hypothesis); and the observation that certain geneExpand
  • 181
  • 20
Looking for Darwin in all the wrong places: the misguided quest for positive selection at the nucleotide sequence level
  • A. Hughes
  • Biology, Medicine
  • Heredity
  • 11 July 2007
Recent years have seen an explosion of interest in evidence for positive Darwinian selection at the molecular level. This quest has been hampered by the use of statistical methods that failExpand
  • 232
  • 20
  • PDF
A new antigen receptor gene family that undergoes rearrangement and extensive somatic diversification in sharks
IMMUNOGLOBULIN and T-cell receptor (TCR) molecules are central to the adaptive immune system. Sequence conservation, similarities in domain structure, and usage of similar recombination signalExpand
  • 516
  • 18
Positive Darwinian selection promotes charge profile diversity in the antigen-binding cleft of class I major-histocompatibility-complex molecules.
Certain major-histocompatibility-complex (MHC) loci are highly polymorphic, and the mechanism of maintenance of this polymorphism remains controversial. Recent studies of the pattern of nucleotideExpand
  • 267
  • 18
  • PDF
Tat-specific cytotoxic T lymphocytes select for SIV escape variants during resolution of primary viraemia
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) infections are characterized by early peaks of viraemia that decline as strong cellular immune responses develop. AlthoughExpand
  • 748
  • 17